Repositorio Principal http://hdl.handle.net/10171/1 2013-05-24T12:21:06Z 2013-05-24T12:21:06Z Barraquer-Bordas, L. (L.) Cañadell, J.M. (J. M.) http://hdl.handle.net/10171/29207 2013-05-24T01:46:20Z 1957-12-31T23:00:00Z

Title: Tratamiento del síndrome de sufrimiento del mediano en el tunel carpiano Author(s) : Barraquer-Bordas, L. (L.); Cañadell, J.M. (J. M.) Abstract: En 3 de los 8 casos se llevó a cabo la intervención quirúrgica: la carnicera, una costurera y el lechero acromegálico (en ambos dedos). Exponemos con detalle la técnica empleada. Los resultados fueron buenos, precoces y brillantes sobre las parestesias, más tardíos y moderados, pero evidentes, sobre las atrofias.

1957-12-31T23:00:00Z Solchaga, L. (L.) Forriol, F. (Francisco) Cañadell, J.M. (J. M.) http://hdl.handle.net/10171/29206 2013-05-24T01:46:19Z 1995-12-31T23:00:00Z

Title: Réparation du cartilage articulaire par matériaux biologiques Author(s) : Solchaga, L. (L.); Forriol, F. (Francisco); Cañadell, J.M. (J. M.) Abstract: The purpose of this study was to assess the joint cartilage's capacity for repair and the potential of various biological tissues as replacements for damaged cartilage. METHODS: We operated 30.3 months old, lambs, creating a chondral lesion which was left untreated in group I and treated with a fresh chondral implant in group III, a frozen chondral implant in group IV, and a frozen periostal implant in group V; in group II the lesion extended as far as the subchondral bone. The lesions were performed in the loading area of the medial condyle of the knee. Follow-up time was 6 months, and the results were assessed histologically. RESULTS: In the chondral lesions which remained untreated (group I), degeneration of the exposed layers occurred, and loss of both cartilage thickness and homogeneity of the matrix was noted. Where the lesion extended as far as the subchondral bone (group II), repair was found to have taken place with a fibrous tissue indistinguishable from cartilage. When cartilage was implanted (group III and IV), the integration of the implant depended on wether there was any contact between the implant and the surrounding tissue. DISCUSSION: The integrity of the fresh implants was maintained better than that of the frozen ones, which were found to contain cells with a proliferative capacity. When periosteum was placed over the chondral lesion, we observed the formation of a very loose fibrous tissue in which the initial stages of differentiation could be appreciated in the deepest layers.

1995-12-31T23:00:00Z Luquin, M.R. (María Rosario) Zbarsky, V. (V.) Garcia-Mardones, N. (N.) http://hdl.handle.net/10171/29205 2013-05-24T01:46:18Z 1997-12-31T23:00:00Z

Title: Conocimientos actuales de la etiopatogenia de la enfermedad de Parkinson Author(s) : Luquin, M.R. (María Rosario); Zbarsky, V. (V.); Garcia-Mardones, N. (N.)

1997-12-31T23:00:00Z Guadarrama-Cetina, J. (José) González-Viñas, W. (Wenceslao) http://hdl.handle.net/10171/29204 2013-05-22T01:23:03Z 2012-12-31T23:00:00Z

Title: Breath figures of two immiscible substances on a repellent surface Author(s) : Guadarrama-Cetina, J. (José); González-Viñas, W. (Wenceslao) Abstract: The understanding of the competition between different substances while condensing on a cold surface is of high interest in situations in which it is desirable to control their condensation rates and the formed morphologies. We do the experiments for mixtures of water and hexamethyldisiloxane vapors at several concentrations. The dropwise condensation of the vapors forms breath figures on a substrate that is repellant to both substances. We report the average radius of the drops for each specie as a function of time. Also, we pay attention to the evolution of the corresponding morphologies and the appearance of hybrid clusters.

2012-12-31T23:00:00Z Luzán-Suescun, R. (Román) http://hdl.handle.net/10171/29199 2013-05-15T08:13:05Z 2012-12-31T23:00:00Z

Title: Inmigrantes en España: territorio y movilidad. Análisis de los perfiles, distribución territorial y movilidad espacial de los inmigrantes residentes en España Author(s) : Luzán-Suescun, R. (Román) Abstract: El presente trabajo plantea el estudio de la movilidad espacial de los inmigrantes residentes en España nacidos en el extranjero, así como los itinerarios migratorios que han seguido algunos de los grupos más numerosos en nuestro país, marroquíes, ecuatorianos, rumanos, franceses, argentinos y británicos. Tanto movilidad como itinerarios presentan una doble vertiente para su estudio: en el ámbito internacional siguiendo a los migrantes desde que abandonan por primera vez su país de nacimiento, y en el nacional, estudiando sus desplazamientos intermunicipales e interprovinciales en España. Para contar con un telón de fondo comprensivo de estos patrones de movilidad, el trabajo presenta también una panorámica de las características de estas poblaciones así como sus pautas de localización y distribución espacial en España. Las fuentes principales que utilizamos son una fuente clásica, el Padrón Municipal y otra novedosa, rica en información y que permite la reconstrucción de la historia de vida de cada inmigrante entrevistado, la Encuesta Nacional de Inmigrantes 2007 (ENI). El estudio comprende la comparación entre los principales orígenes migratorios mediante el análisis de la distribución por periodo de llegada, momento de acceso a la nacionalidad española, edad media de llegada a nuestro país, patrón de migración familiar, índice de nivel de estudios por sexo, situación en relación con la actividad, intensidad migratoria internacional, intermunicipal e interprovincial y, por fin, las características de los inmigrantes según hayan migrado directamente, vivido en otro país aparte del de origen, y en dos o más. También se analizan las características de los inmigrantes que no se mueven de su municipio o provincia de llegada y de quienes sí lo hacen. Estas últimas comparaciones se realizan entre el grupo estático y el dinámico y entre los distintos orígenes migratorios. Los resultados de la investigación muestran cómo los distintos patrones migratorios responden a factores explicativos diferentes, en gran parte asociados al país de origen. Sin embargo, también hay diversidad dentro de un mismo origen. Estos contrastes internos son en algunos casos fruto de la heterogeneidad en el grupo, el caso francés; en otros, Argentina por ejemplo, se debe a la variedad de perfiles asociados al calendario migratorio y las causas de estas migraciones; a estrategias migratorias en el contexto de redes sociales los rumanos; o a contextos culturales marcados por diferencias de género, los marroquíes. Otro de los factores que explican los variados patrones de movilidad está asociado a cadenas migratorias de retorno de generaciones anteriores, segunda o tercera.----------------------This doctoral dissertation presents the study of the spatial mobility of foreing-born immigrants (Moroccan, Ecuadorian, Romanian, French, Argentinians and British) living in Spain, and their migratory itineraries. Mobility and routes have two geographical perspectives to their study, at the international level, following immigrants since they first came out of their country of birth, and at the national level studying their intermunicipal and interprovincial movements after their arrival in Spain. To provide a comprehensive backdrop of these mobility patterns, the work also presents an overview of the characteristics of these populations and their localization patterns and spatial distribution in Spain. The main sources we use are a classical source, the Municipal Register, and a novel one, the National Immigrant Survey, rich in information that allows the reconstruction of the life history of each immigrant interviewed. The study includes a comparison of the main migratory origins by analyzing the distribution by period of arrival, time of access to Spanish nationality, average age of arrival in Spain, family migration patterns, educational attainment index by sex, situation in relation to the activity, intensity of international and inter-municipal migration and, finally, the characteristics of immigrants who migrated directly, lived in another country, and in two or more. It also analyzes the characteristics of immigrants who do not move from their municipality or province of arrival and those who do. The latter comparisons are made between stayers and dynamics between different origins and migration. The research results show how different migration patterns respond to different explanatory factors, largely associated with the country of origin. These internal contrasts are sometimes the result of heterogeneity in the group, the French case; in others, such as the Argentina, due to the variety of profiles associated with migration timing and causes of this migration; due to internal migration strategies in the context of social networks, case of the Romanians, or cultural contexts marked by gender differences, the Moroccans. Another factor explaining the various patterns of mobility is associated with return migration chains of previous generations, second or third.

2012-12-31T23:00:00Z Vázquez-del-Rey-Villanueva, A. (Antonio) http://hdl.handle.net/10171/29198 2013-05-14T07:05:27Z 2011-12-31T23:00:00Z

Title: Revisión crítica de las concepciones habituales sobre el IVA Author(s) : Vázquez-del-Rey-Villanueva, A. (Antonio) Abstract: La concepción jurídica del IVA se ha visto tradicionalmente lastrada tanto por una serie de referencias y planteamientos de origen económico como por aproximaciones excesivamente formalistas. Desde una perspectiva jurídica, no estamos ante un impuesto sobre el volumen de negocios, como habitualmente se sostiene en el ámbito comunitario. Por otra parte, desde un punto de vista jurídico, es preciso distinguir entre el objeto-fin del IVA, que apunta a su consideración como impuesto sobre el consumo, y el mecanismo a través del cual se pretende gravar el consumo. En el primer caso, es preciso no sobredimensionar la importancia de ciertas excepciones al normal funcionamiento del IVA, puesto que ello conduce a una visión distorsionada de la justificación del gravamen desde el punto de vista del principio de capacidad económica. Por lo que se refiere al mecanismo a través del cual se grava el consumo, no cabe aceptar las cons - trucciones jurídicas más extendidas, cuyo excesivo formalismo también conduce a una visión incorrecta. La realización del presupuesto de hecho conlleva, salvo excepción, la obligación de pagar la cuota tributaria. No obstante, la presencia de dos elementos esenciales dentro del IVA, como son la repercusión y la deducción, no permite encuadrar los elementos estructurales del IVA dentro de las categorías tributarias tradicionales.-------------------------The legal approach to VAT has been traditionally weighed down by some economic considerations as well as by a too formalistic approach. From that perspective, VAT should not be regarded as a turnover tax, as it is usually seen in the EU environment. Moreover, for the purposes of a legal approach it is necessary to differentiate between the goal of VAT, which is to levy a tax on consumption, and the mechanism by which that result is intended. In the first case, one must not oversize the existence of some exceptions to the ordinary functioning of VAT; otherwise, there is a risk of distorting the truth as regards the justification of the tax on the ability to pay principle. Regarding specifically the tax mechanism, the most widespread notion cannot be accepted either as its excessive formalism also leads to a somehow distorted view. The chargeable event always involves the payment of the tax, however, both the collection from customers and the right of deduction are key elements which do not allow categorizing VAT ́s legal structure within the traditional tax law categories.

2011-12-31T23:00:00Z Migliaccio, M.I. (María Inés) http://hdl.handle.net/10171/29186 2013-05-10T00:50:57Z 2012-12-31T23:00:00Z

Title: Fundamentos antropológicos de la moda: magnanimidad y elegancia Author(s) : Migliaccio, M.I. (María Inés) Abstract: Esta tesis trata de la magnanimidad y de la elegancia como virtudes fundamentales para el cumplimiento del papel insustituible de cada persona en el protagonismo de una moda digna y bella, que puede contribuir en mucho al desarrollo de una sociedad más feliz. Al profundizar en el presupuesto de que ‘las virtudes son para los hombres, lo que las instituciones son para la sociedad’, por medio de una relación novedosa entre los trascendentales metafísicos aristotélicotomistas: ser, bondad, belleza y unidad, y los trascendentales sociales que propone Rafael Alvira: historia, educación, cultura y civilización, descubrimos la grandeza de ánimo, el ornato de las virtudes: la magnanimidad, así como la capacidad de elegir lo mejor: la elegancia, como fundamentos antropológicos de la moda. Él análisis histórico-sociológico de cuatro pilares de este sector económico –los gestores, los creadores, los informadores y los consumidores de la moda– comprobó nuestra teoría, sintetizada por el perfil de sus más comunes manifestaciones y por los fenómenos que implican, como el tiempo, el espacio, el servicio, la fiesta, el lujo y, finalmente, el amor. ---------------------------------------This thesis deals with magnanimity and elegance as fundamental virtues for the fulfilment of the irreplaceable role of each person in the prominence of a beautiful and worthy fashion, which can contribute to the development of a happier society. Upon deepening in the hypothesis that ‘virtues are for men, what the institutions are for society’, through a novel relation among the transcendental metaphysical aristotelian-thomistic: to be, kindness, beauty and unity; and the transcendental social that has been proposes by Rafael Alvira: history, education, culture and civilization, we discover the greatness of spirit, the adornment of virtues: the magnanimity, as well as the capacity of electing the best: the elegance, as anthropological bases of the fashion.The historical-sociological analysis of four pillars of this economic sector –the managers, the creators or designers, the communicators and the consumers of fashion– verified our theory, synthesized by the profile or their more common demonstrations and by the phenomena that imply, like time, space, service, celebration, luxury and, finally, love.

2012-12-31T23:00:00Z Aurell, J. (Jaume) Rubiés, J.P. (Joan-Pau) http://hdl.handle.net/10171/29183 2013-05-09T00:46:40Z 1992-12-31T23:00:00Z

Title: Els mercaders catalans i la cultura, de l'edat mitjana al renaixement Author(s) : Aurell, J. (Jaume); Rubiés, J.P. (Joan-Pau) Abstract: El estudio de los mercaderes medievales a menudo ha sufrido una distorsión derivada de la imagen de los agentes económicos precapitalistas cuyo comportamiento es inspirado por valores culturales típicamente burgueses. Sobre la base de una definición más rigurosa de este grupo social, este artículo utiliza el caso de la Barcelona medieval con el fin de desarrollar una hipótesis sobre la evolución de los comerciantes a lo largo de la crisis de la Baja Edad Media y el comienzo del Renacimiento. El análisis busca relacionar modelos predominantes de la movilidad social con la identidad política de la ciudad medieval y la característica de la cultura de los comerciantes. Así, el artículo establece un modelo dinámico en el que el papel social del comerciante-empresario abierto a riesgos se relativiza con referencia a un modelo de ascenso social que es patricio-rentista y finalmente aristocrático. Este proceso se interpreta a la luz de la evolución particular de la Corona de Aragón a través de la crisis de la Baja Edad Media y los siguientes siglos, destacando, por un lado, la precariedad de Barcelona como centro económico y, por otro lado, la fracaso político del modelo de cooperación entre la monarquía feudal y los comerciantes autónomos que había caracterizado el período de expansión. A partir de este contexto, la evolución cultural de los mercaderes de Barcelona, es interpretada mediante el análisis de los inventarios de sus bibliotecas. Hacemos hincapié en un notable nivel de lectura a finales de los siglos XIV y XV. El universo moral de estos comerciantes puede ser caracterizado por la combinación de la piedad cristiana y una especie de actitud utilitarista, que parecía estar regulada por el discurso clerical de autores influyentes como Francesc Eiximenis. Con la decadencia política de los comerciantes como grupo social, y en el contexto del Renacimiento pleno, hubo sin embargo una consolidación de su tendencia a la mediocridad cultural. ------------------------------------------ The study of medieval merchants has often suffered from a distortion derived from the image of pre-capitalist economic agents whose behaviour is inspired by typically bourgeois cultural values. On the basis of a more rigorous definition of this social group, this article uses the case of medieval Barcelona in order to develop an hypothesis concerning the evolution of merchants throughout the late medieval crisis and the beginning of the Renaissance. The analysis seeks to relate predominant models of social mobility with the political identity of the medieval city and the culture characteristic of merchants. Thus, the article establishes a dynamic model in which the social role of the merchant-entrepreneur open to risks is relativised with reference to a model of social ascent which is patrician-rentier and ultimately aristocratic. This process is interpreted in the light of the particular evolution of the Crown of Aragon through the late medieval crisis and the following centuries, stressing, on the one hand, the precariousness of Barcelona as an economic centre, and, on the other hand, the political failure of the model of cooperation between feudal monarchy an autonomous merchants which had characterised the period of expansion. From this context, the cultural evolution of the merchants of Barcelona is interpreted by analysing inventories of their libraries. We stress a remarkable level of reading during the late fourteenth and fifteenth centuries. The moral universe of these merchants can be characterised by the combination of Christian piety and a kind of utilitarian attitude, which seemed to be regulated by the clerical discourse of influential authors like Francesc Eiximenis. With the political decadence of merchants as a social group, and in the context of the full Renaissance, there was however a consolidation of their tendency towards cultural mediocrity.

1992-12-31T23:00:00Z Llamas-Saíz, C. (Carmen) http://hdl.handle.net/10171/29182 2013-05-09T00:46:07Z 2011-12-31T23:00:00Z

Title: Las partículas discursivas en el Vocabulario Navarro de José María Iribarren Author(s) : Llamas-Saíz, C. (Carmen)

2011-12-31T23:00:00Z Fanjul, C. (Carmen) Barrenetxe, J. (Jaione) Lostao, M.P. (María Pilar) http://hdl.handle.net/10171/29164 2013-05-07T00:45:50Z 2012-12-31T23:00:00Z

Title: Basal leptin regulates amino acid uptake in polarized Caco-2 cells Author(s) : Fanjul, C. (Carmen); Barrenetxe, J. (Jaione); Lostao, M.P. (María Pilar) Abstract: Leptin is secreted by gastric mucosa and is able to reach the intestinal lumen where its receptors are located in the apical membrane of the enterocytes. We have previously demonstrated that apical leptin inhibits sugar and amino acids uptake in vitro and glucose absorption in vivo. Since leptin receptors are also expressed in the basolateral membrane of the enterocytes, the aim of the present work was to investigate whether leptin acting from the basolateral side could also regulate amino acid uptake. Tritiated Gln and β-Ala were used to measure uptake into Caco-2 cells grown on filters, in the presence of basal leptin at short incubation times (5 and 30 min) and after 6 h of preincubation with the hormone. In order to compare apical and basal leptin effect, Gln and β-Ala uptake was measured in the presence of leptin acting from the apical membrane also in cells grown on filters. Basal leptin (8 mM) inhibited by ~15–30 % the uptake of 0.1 mM Gln and 1 mM β-Ala quickly, after 5 min exposure, and the effect was maintained after long preincubation periods. Apical leptin had the same effect. Moreover, the inhibition was rapidly and completely reversed when leptin was removed from the apical or basolateral medium. These results extend our previous findings and contribute to the vision of leptin as an important hormonal signal for the regulation of intestinal absorption of nutrients.

2012-12-31T23:00:00Z Fanjul, C. (Carmen) Barrenetxe, J. (Jaione) Iñigo, C. (Carmen) Sakar, Y. (Yassine) Ducroc, R. (Robert) Barber, A. (Ana) Lostao, M.P. (María Pilar) http://hdl.handle.net/10171/29163 2013-05-07T00:45:49Z 2011-12-31T23:00:00Z

Title: Leptin regulates sugar and amino acids transport in the human intestinal cell line Caco-2 Author(s) : Fanjul, C. (Carmen); Barrenetxe, J. (Jaione); Iñigo, C. (Carmen); Sakar, Y. (Yassine); Ducroc, R. (Robert); Barber, A. (Ana); Lostao, M.P. (María Pilar) Abstract: Aim: Studies in rodents have shown that leptin controls sugars and glutamine entry in the enterocytes by regulating membrane transporters. Here, we have examined the effect of leptin on sugar and amino acids absorption in the human model of intestinal cells Caco-2 and investigated the transporters involved. Methods: Substrate uptake experiments were performed in Caco-2 cells, grown on plates, in the presence and the absence of leptin and the expression of the different transporters in brush border membrane vesicles was analysed by Western blot. Results: Leptin inhibited 0.1 mM α-methyl-D-glucoside uptake after 5 or 30 min treatment, and decreased SGLT1 protein abundance in the apical membrane. Uptake of 20 µM glutamine and 0.1 mM phenylalanine was also inhibited by leptin, indicating sensitivity to the hormone of the Na+-dependent neutral amino acid transporters ASCT2 and B0AT1. This inhibition was accompanied by a reduction of the transporters expression at the brush-border membrane. Leptin also inhibited 1 mM proline and β-alanine uptake in Na+ medium at pH 6, conditions for optimal activity of the H+-dependent neutral amino acid transporter PAT1. In this case, abundance of PAT1 in the brush-border membrane after leptin treatment was not modified. Interestingly, leptin inhibitory effect on β-alanine uptake was reversed by the PKA inhibitor H-89 suggesting involvement of PKA pathway in leptin´s regulation of PAT1 activity. Conclusion: These data show in human intestinal cells that leptin can rapidly control the activity of physiologically relevant transporters for rich-energy molecules, i.e D-glucose (SGLT1) and amino acids (ASCT2, B0AT1 and PAT1).

2011-12-31T23:00:00Z Pujol-Gimenez, J. (Jonai) Barrenetxe, J. (Jaione) Gonzalez-Muniesa, P. (Pedro) Lostao, M.P. (María Pilar) http://hdl.handle.net/10171/29162 2013-05-07T00:45:32Z 2012-12-31T23:00:00Z

Title: The facilitated glucose transporter GLUT12: What do we know and what would we like to know? Author(s) : Pujol-Gimenez, J. (Jonai); Barrenetxe, J. (Jaione); Gonzalez-Muniesa, P. (Pedro); Lostao, M.P. (María Pilar) Abstract: Human GLUT12 was isolated from the breast cancer cell line MCF-7 by its homology with GLUT4. Glucose has been described as its main substrate, but it also can transport other sugars. In humans, GLUT12 protein is expressed mainly in insulin sensitive tissues. Functional analysis has showed that GLUT12 transports sugars down its concentration gradient, but it can also work as a proton-coupled symporter. Studies from our laboratory, performed in Xenopus laevis oocytes expressing GLUT12, show that glucose uptake increases in the presence of Na+ and induces inward current. These findings suggest a transport mechanism never described for other GLUTs, which would indicate a distinct functional role for GLUT12. In relation with its physiological and pathophysiological function, GLUT12 has been mainly studied due to its role as a secondary insulin-sensitive glucose transporter and its possible implication in impaired insulin signalling pathologies. Its expression in some tumour tissues has been described and recently, it has been proposed as one of the key proteins in the glucose supply to malignant cells. Overall, even though a lot of information about GLUT12 has been released during the last years, its functional characteristics, physiological role or implication in the development of some diseases is still unclear. Therefore, this review of the literature can help to address further investigations needed to elucidate these issues that, in our view, are of great interest mainly due to the direct GLUT12 relation with cancer and probably with diabetes development.

2012-12-31T23:00:00Z Estella-Hermoso-de-Mendoza, A. (Ander) Campanero, M.A. (Miguel Angel) Lana, H. (Hugo) Villa-Pulgarin, J.A. (Janny A.) Iglesia-Vicente, J. (Janis) de la Mollinedo, F. (Faustino) Blanco-Prieto, M.J. (María José) http://hdl.handle.net/10171/29159 2013-05-07T00:19:41Z 2011-12-31T23:00:00Z

Title: Complete inhibition of extranodal dissemination of lymphoma by edelfosine-loaded lipid nanoparticles Author(s) : Estella-Hermoso-de-Mendoza, A. (Ander); Campanero, M.A. (Miguel Angel); Lana, H. (Hugo); Villa-Pulgarin, J.A. (Janny A.); Iglesia-Vicente, J. (Janis) de la; Mollinedo, F. (Faustino); Blanco-Prieto, M.J. (María José) Abstract: Lipid nanoparticles (LN) made of synthetic lipids Compritol® 888 ATO and Precirol® ATO 5 were developed, presenting an average size of 110.4 ± 2.1 nm and 103.1 ± 2.9 nm, for Compritol® and Precirol®, respectively, and encapsulation efficiency above 85 % for both type of lipids. These LN decrease the hemolytic toxicity of the drug by 90 %. Pharmacokinetic and biodistribution profiles of the drug were studied after intravenous and oral administration of edelfosine-containing LN, providing an increase in relative oral bioavailability of 1500 % after a single oral administration of drug-loaded LN, maintaining edelfosine plasma levels over 7 days in contrast to a single oral administration of edelfosine solution, which presents a relative oral bioavailability of 10 %. Moreover, edelfosine-loaded LN showed a high accumulation of the drug in lymph nodes and resulted in slower tumor growth than the free drug in a murine lymphoma xenograft model, as well as potent extranodal dissemination inhibition.

2011-12-31T23:00:00Z Puchau, B. (Blanca) Zulet, M.A. (María Ángeles) Gonzalez-de-Echavarri, A. (Amaia) Hermsdorff, H.H. (H.H.) Martinez, J.A. (José Alfredo) http://hdl.handle.net/10171/29158 2013-05-07T00:09:33Z 2008-12-31T23:00:00Z

Title: Dietary total antioxidant capacity: a novel indicator of diet quality in healthy young adults Author(s) : Puchau, B. (Blanca); Zulet, M.A. (María Ángeles); Gonzalez-de-Echavarri, A. (Amaia); Hermsdorff, H.H. (H.H.); Martinez, J.A. (José Alfredo) Abstract: Background: Overall diet quality measurements have been suggested as a useful tool to assess diet-disease relationships. Oxidative stress has been related to the development of obesity and other chronic diseases. Furthermore, antioxidant intake is being considered as protective against cell oxidative damage and related metabolic complications. Objective: To evaluate potential associations between the dietary total antioxidant capacity of foods (TAC), the energy density of the diet, and other relevant nutritional quality indexes in healthy young adults. Methods: Several anthropometric variables front 153 healthy participants (20.8 +/- 2.7 years) included in this study were measured. Dietary intake was assessed by a validated food-frequency questionnaire, which was also used to calculate the dietary TAG and for daily energy intake adjustment. Results: Positive significant associations were found between dietary TAG and Mediterranean energy density hypothesis oriented dietary scores (Mediterranean Diet Score, Alternate Mediterranean Diet Score, Modified Mediterranean Diet Score), non-Mediterranean hypothesis oriented dietary scores (Healthy Eating Index, Alternate Healthy Eating Index. Diet Quality Index-International, Diet Quality Index-Revised), and diversity of food intake indicators (Recommended Food Score, Quantitative Index for Dietary Diversity in terms of total energy intake). The Mediterranean Diet Quality Index and Diet Quality Index scores (a Mediterranean and a non Mediterranean hypothesis oriented dietary score, respectively), whose lower values refer to a higher diet quality, decreased with higher values of dietary TAG. Energy density was also inversely associated with dietary TAG. Conclusion: These data suggest that dietary TAG, as a measure of antioxidant intake, may also be a potential marker of diet quality in healthy subjects, providing a novel approach to assess the role of antioxidant intake on health promotion and diet-based therapies.

2008-12-31T23:00:00Z Kovács, K. (Kornél) Cruz-Hidalgo, R. (Raúl) Pagonabarraga, I. (Ignacio) Kun, F. (Ferenc) http://hdl.handle.net/10171/29157 2013-05-03T09:47:50Z 2013-04-28T22:00:00Z

Title: Brittle-to-ductile transition in a fiber bundle with strong heterogeneity Author(s) : Kovács, K. (Kornél); Cruz-Hidalgo, R. (Raúl); Pagonabarraga, I. (Ignacio); Kun, F. (Ferenc) Abstract: We analyze the failure process of a two-component system with widely different fracture strength in the framework of a fiber bundle model with localized load sharing. A fraction 0 α 1 of the bundle is strong and it is represented by unbreakable fibers, while fibers of the weak component have randomly distributed failure strength. Computer simulations revealed that there exists a critical composition αc which separates two qualitatively different behaviors: Below the critical point, the failure of the bundle is brittle, characterized by an abrupt damage growth within the breakable part of the system. Above αc, however, the macroscopic response becomes ductile, providing stability during the entire breaking process. The transition occurs at an astonishingly low fraction of strong fibers which can have importance for applications. We show that in the ductile phase, the size distribution of breaking bursts has a power law functional form with an exponent μ = 2 followed by an exponential cutoff. In the brittle phase, the power law also prevails but with a higher exponent μ = 9 2. Thetransition between the two phases shows analogies to continuous phase transitions. Analyzing the microstructure of the damage, it was found that at the beginning of the fracture process cracks nucleate randomly, while later on growth and coalescence of cracks dominate, which give rise to power law distributed crack sizes.

2013-04-28T22:00:00Z