http://hdl.handle.net/10171/18882 2013-05-23T22:31:14Z 2013-05-23T22:31:14Z Muñoz-Navas, M.A. (Miguel) Baillie, J. (J.) http://hdl.handle.net/10171/28050 2013-03-01T02:31:35Z 1999-12-31T23:00:00Z

Title: Abdominal pain and abnormal liver tests after orthotopic liver transplantation Author(s) : Muñoz-Navas, M.A. (Miguel); Baillie, J. (J.)

1999-12-31T23:00:00Z Muñoz-Navas, M.A. (Miguel) Macias, E. (Elena) Garcia-Villarreal, L. (Luis) Angos, R. (Ramón) http://hdl.handle.net/10171/28046 2013-03-01T02:32:33Z 1992-12-31T23:00:00Z

Title: Endoscopic diagnosis and extraction of gastric parasites Author(s) : Muñoz-Navas, M.A. (Miguel); Macias, E. (Elena); Garcia-Villarreal, L. (Luis); Angos, R. (Ramón)

1992-12-31T23:00:00Z Jimenez-Perez, F.J. (F. J.) Muñoz-Navas, M. (Miguel) http://hdl.handle.net/10171/28045 2013-03-01T02:32:45Z 1990-12-31T23:00:00Z

Title: Endoscopic diagnosis of gastric peptic ulcer penetrating into the liver Author(s) : Jimenez-Perez, F.J. (F. J.); Muñoz-Navas, M. (Miguel) Abstract: A 61-year-old man was admitted with upper gastrointestinal bleeding. Endoscopy showed a large gastric peptic ulcer with a pseudotumoral mass protruding from the ulcer bed. Histological examination of biopsies taken from the mass revealed distorted hepatic tissue and inflammatory changes. Hepatic penetration was diagnosed as the cause of bleeding. Surgery findings confirmed the endoscopic diagnosis.

1990-12-31T23:00:00Z Muñoz-Navas, M. (Miguel) Jimenez-Perez, F.J. (F. J.) Sagues, J. (J.) Zozaya, J.M. (José Manuel) http://hdl.handle.net/10171/28040 2013-02-28T01:40:51Z 1986-12-31T23:00:00Z

Title: Upper gastrointestinal hemorrhage associated with fistula formation in the duodenum due to a catheter placed in the hepatic artery Author(s) : Muñoz-Navas, M. (Miguel); Jimenez-Perez, F.J. (F. J.); Sagues, J. (J.); Zozaya, J.M. (José Manuel)

1986-12-31T23:00:00Z Cañadell, J.M. (J. M.) Moreno-Londoño, A. (Álvaro) Gonzalez-Caudevilla, B. (Bosco) http://hdl.handle.net/10171/28038 2013-02-28T01:40:48Z 1990-12-31T23:00:00Z

Title: Ketorolac, a new non-opioid analgesic: a single-blind trial versus buprenorphine in pain after orthopaedic surgery Author(s) : Cañadell, J.M. (J. M.); Moreno-Londoño, A. (Álvaro); Gonzalez-Caudevilla, B. (Bosco) Abstract: A randomized single-blind, double-observer trial was performed to evaluate the efficacy of a new non-steroidal anti-inflammatory analgesic drug, ketorolac, in the treatment of post-orthopaedic surgery pain. Sixty patients with moderate to severe pain were studied; 30 patients were treated with ketorolac at a dose of 30 mg intramuscularly up to 4-times a day, whilst the other 30 patients received 0.3 mg buprenorphine intramuscularly up to 4-times a day. A significant reduction in the severity of the pain was recorded in both groups. Throughout the study, comparable efficacy was found between the two therapies although buprenorphine showed greater efficacy during the first 8 hours. Interestingly, the withdrawals due to adverse events were significantly less in the ketorolac group (p less than 0.001). This study, therefore, suggests that ketorolac may be a useful and more acceptable alternative to buprenorphine in the treatment of post-orthopaedic surgery pain.

1990-12-31T23:00:00Z Balen, E. (Enrique) Cienfuegos, J.A. (Javier A.) Pardo, F. (Fernando) Gonzalez, J. (J). Villa, V.H. (V. H.) de Hernandez-Lizoain, J.L. (José Luis) Torramade, J. (J.) Zornoza, G. (Gerardo) Calvo, F.A. (Felipe A.) http://hdl.handle.net/10171/28037 2013-02-28T01:40:11Z 1992-12-31T23:00:00Z

Title: Cirugía derivativa más radioterapia intraoperatoria y externa en el carcinoma de páncreas localizado e irresecable Author(s) : Balen, E. (Enrique); Cienfuegos, J.A. (Javier A.); Pardo, F. (Fernando); Gonzalez, J. (J).; Villa, V.H. (V. H.) de; Hernandez-Lizoain, J.L. (José Luis); Torramade, J. (J.); Zornoza, G. (Gerardo); Calvo, F.A. (Felipe A.) Abstract: Presentamos una serie de 25 casos de carcinomas de páncreas localmente avanzados e irresecables, sin metástasis a distancia, tratados con cirugía derivativa, radioterapia intraoperatoria e irradiación externa: 18 tumores de cabeza (16 con ictericia obstructiva) y 7 de cuerpo. Se realizó derivación biliar en 18 y gastroyeyunostomía en 19. La mortalidad operatoria fue nula, con una morbilidad del 16%. A largo plazo se produjeron 3 hemorragias digestivas, 2 ictericias obstructivas, una colangitis y una obstrucción intestinal. Se obtuvo un 72% de control local de la enfermedad y todos los fallecidos por progresión tumoral desarrollaron metástasis hepáticas y/o peritoneales. Presentaban dolor pancreático 22 pacientes y 20 experimentaron remisión del mismo en una a 2 semanas. La analgesia fue definitiva en 12 y reapareció el dolor tardíamente en ocho. La supervivencia media fue de 9 meses (rango 4-24). La revisión de la literatura pone de manifiesto la indicación de la radioterapia externa tanto en el carcinoma de páncreas irresecable y no metastásico como en los resecados. La asociación de radioterapia intraoperatoria tiene, así mismo, un papel importante en cuanto a supervivencia, paliación del dolor y de la progresión local. El 5-fluorouracilo asociado al tratamiento radioterápico prolonga significativamente la supervivencia con una morbilidad razonable.

1992-12-31T23:00:00Z Albiach, M. (M.) Benito, C. (C.) Gonzalez, J. (J.) Balen, E. (Enrique) Pardo, F. (Fernando) Cienfuegos, J.A. (Javier A.) Hernandez-Lizoain, J.L. (José Luis) Voltas, J. (J.) http://hdl.handle.net/10171/28036 2013-02-28T01:40:39Z 1990-12-31T23:00:00Z

Title: Acceso venoso central mediante cápsulas de inyección subcutáneas. Serie de 124 dispositivos Author(s) : Albiach, M. (M.); Benito, C. (C.); Gonzalez, J. (J.); Balen, E. (Enrique); Pardo, F. (Fernando); Cienfuegos, J.A. (Javier A.); Hernandez-Lizoain, J.L. (José Luis); Voltas, J. (J.) Abstract: Presentamos una serie de 111 pacientes (límites: 9 meses - 78 años) en los que se colocaron 124 dispositivos como modalidad de acceso venoso central. Se analizan las complicaciones aparecidas durante su utilización, que actualmente sobrepasa los 1.100 meses, y se comentan aspectos técnicos de colocación con influencia sobre la morbilidad del sistema. La media actual de funcionamiento se sitúa en 9,9 meses por persona, con una tasa de complicaciones del 19 %.

1990-12-31T23:00:00Z Prieto, C. (César) Fernandez-Urien, I. (Ignacio) Sangro, B. (Bruno) Subtil, J.C. (José Carlos) Idoate, M.A. (Miguel A.) Cano, D. (David) Muñoz-Navas, M. (Miguel) http://hdl.handle.net/10171/27992 2013-02-26T01:35:54Z 1997-12-31T23:00:00Z

Title: Pneumatosis coli due to pharmacological constipation Author(s) : Prieto, C. (César); Fernandez-Urien, I. (Ignacio); Sangro, B. (Bruno); Subtil, J.C. (José Carlos); Idoate, M.A. (Miguel A.); Cano, D. (David); Muñoz-Navas, M. (Miguel)

1997-12-31T23:00:00Z Muñoz-Navas, M. (Miguel) Garcia-Villarreal, L. (Luis) http://hdl.handle.net/10171/27977 2013-02-26T01:36:41Z 1991-12-31T23:00:00Z

Title: Caustic colitis due to formalin enema Author(s) : Muñoz-Navas, M. (Miguel); Garcia-Villarreal, L. (Luis)

1991-12-31T23:00:00Z Herrero, J.I. (José Ignacio) Pardo, F. (Fernando) D'Avola, D. (Delia) Alegre, F. (Félix) Rotellar, F. (Fernando) Iñarrairaegui, M. (Mercedes) Marti, P. (Pablo) Sangro, B. (Bruno) Quiroga, J. (Jorge) http://hdl.handle.net/10171/27544 2013-01-03T01:12:18Z 2010-12-31T23:00:00Z

Title: Risk factors of lung, head and neck, esophageal, and kidney and urinary tract carcinomas after liver transplantation: the effect of smoking withdrawal Author(s) : Herrero, J.I. (José Ignacio); Pardo, F. (Fernando); D'Avola, D. (Delia); Alegre, F. (Félix); Rotellar, F. (Fernando); Iñarrairaegui, M. (Mercedes); Marti, P. (Pablo); Sangro, B. (Bruno); Quiroga, J. (Jorge) Abstract: Liver transplant recipients have an increased risk of malignancy. Smoking is related to some of the most frequent causes of posttransplant malignancy. The incidence and risk factors for the development of neoplasia related to smoking (head and neck, lung, esophageal, and kidney and urinary tract carcinomas) were studied in 339 liver transplant recipients. Risk factors for the development of smoking-related neoplasia were also studied in 135 patients who had a history of smoking so that it could be determined whether smoking withdrawal was associated with a lower risk of malignancy. After a mean follow-up of 7.5 years, 26 patients were diagnosed with 29 smoking-related malignancies. The 5- and 10-year actuarial rates were 5% and 13%, respectively. In multivariate analysis, smoking and older age were independently associated with a higher risk of malignancy. In the smoker subgroup, the variables related to a higher risk of malignancy were active smoking and older age. In conclusion, smoking withdrawal after liver transplantation may have a protective effect against the development of neoplasia.

2010-12-31T23:00:00Z Cuernas-Monos, V.(V) Cienfuegos, J.A. (Javier A.) Maganto, P. (P.) Golitsin, A. (A.) Eroles, G. (G.) Castillo-Olivares, J.L. (J. L.) Segovia-de-Arana, J.M. (J. M.) http://hdl.handle.net/10171/27508 2012-12-21T01:08:06Z 1983-12-31T23:00:00Z

Title: Time-related efficacy of liver cell isografts in fulminant hepatic failure Author(s) : Cuernas-Monos, V.(V); Cienfuegos, J.A. (Javier A.); Maganto, P. (P.); Golitsin, A. (A.); Eroles, G. (G.); Castillo-Olivares, J.L. (J. L.); Segovia-de-Arana, J.M. (J. M.) Abstract: We and others have reported that dispersed liver cells transplanted into the spleen parenchyma of syngeneic rats remained functional and viable for a long time. This report describes our results with hepatocellular transplantation as a therapeutic method in a model of fulminant hepatic failure (FHF) in the rat. 60 male Sprague-Dawley rats weighing 200-250 g were used. The FHF was reached through an Eck's fistula with 2/3 hepatectomy at the same time. This model produced lethal hepatic failure in a highly reproducible manner. Liver cells were isolated by the collagenase method. 40 X 10(6) hepatocytes suspended in Hanks' balanced salt solution were transplanted into the spleen parenchyma 24 hr before (group 1), at the same time as (group 2), and 24 hr after (group 3) FHF was achieved. Additional sham-operated animals (groups 4 and 5) and a control group (group 6) were used. The hepatocellular transplantation markedly increased the survival of the animals with induced FHF to 80% (group 1) and 60% (group 2)--but not in group 3 (20%),--compared with 10% in the control group. This study shows that dispersed liver cells transplanted into the spleen can provide sufficient support to allow animals with lethal hepatic failure to survive and recover. Nevertheless the efficacy of transplantation is a time-related phenomenon with the FHF induction.

1983-12-31T23:00:00Z Muñoz-Navas, M. (Miguel) Jimenez-Perez, F.J. (F. J.) Lecumberri, F.J. (F. J.) http://hdl.handle.net/10171/27493 2013-02-27T14:07:29Z 1988-12-31T23:00:00Z

Title: Portal venous gas secondary to a penetrating foreign body of the stomach Author(s) : Muñoz-Navas, M. (Miguel); Jimenez-Perez, F.J. (F. J.); Lecumberri, F.J. (F. J.)

1988-12-31T23:00:00Z Pons-Beltran, V. (Vicente) Gonzalez-Suarez, B. (Begoña) Gomez-Asanza, C. (Cecilia) Perez-Cuadrado, V. (V.) Fernandez-Diez, S. (Servando) Fernandez-Urien, I. (Ignacio) Mata-Bilbao, A. (Alfredo) Espinos-Perez, J.C. (Jorge Carlos) Perez-Grueso, M.J. (María José) Arguello-Viudez, L. (Lidia) Valle-Muñoz, J. (Julio) Carballo-Alvarez, F. (Fernando) Muñoz-Navas, M. (Miguel) Llach-Vila, J. (José) Ramirez-Armengol, J.A. (Juan Andrés) Balanzo-Tintore, J. (Joaquin) Sala-Felix, T. (Teresa) Menchen, P. (Pedro) http://hdl.handle.net/10171/27490 2012-12-20T11:34:35Z 2010-12-31T23:00:00Z

Title: Evaluation of different bowel preparations for small bowel capsule endoscopy: a prospective, randomized, controlled study Author(s) : Pons-Beltran, V. (Vicente); Gonzalez-Suarez, B. (Begoña); Gomez-Asanza, C. (Cecilia); Perez-Cuadrado, V. (V.); Fernandez-Diez, S. (Servando); Fernandez-Urien, I. (Ignacio); Mata-Bilbao, A. (Alfredo); Espinos-Perez, J.C. (Jorge Carlos); Perez-Grueso, M.J. (María José); Arguello-Viudez, L. (Lidia); Valle-Muñoz, J. (Julio); Carballo-Alvarez, F. (Fernando); Muñoz-Navas, M. (Miguel); Llach-Vila, J. (José); Ramirez-Armengol, J.A. (Juan Andrés); Balanzo-Tintore, J. (Joaquin); Sala-Felix, T. (Teresa); Menchen, P. (Pedro) Abstract: To obtain an adequate view of the whole small intestine during capsule endoscopy (CE) a clear liquid diet and overnight fasting is recommended. However, intestinal content can hamper vision in spite of these measures. Our aim was to evaluate tolerance and degree of intestinal cleanliness during CE following three types of bowel preparation. PATIENTS AND METHODS: This was a prospective, multicenter, randomized, controlled study. Two-hundred ninety-one patients underwent one of the following preparations: 4 L of clear liquids (CL) (group A; 92 patients); 90 mL of aqueous sodium phosphate (group B; 89 patients); or 4 L of a polyethylene glycol electrolyte solution (group C; 92 patients). The degree of cleanliness of the small bowel was classified by blinded examiners according to four categories (excellent, good, fair or poor). The degree of patient satisfaction, gastric and small bowel transit times, and diagnostic yield were measured. RESULTS: The degree of cleanliness did not differ significantly between the groups (P = 0.496). Interobserver concordance was fair (k = 0.38). No significant differences were detected between the diagnostic yields of the CE (P = 0.601). Gastric transit time was 35.7 +/- 3.7 min (group A), 46.1 +/- 8.6 min (group B) and 34.6 +/- 5.0 min (group C) (P = 0.417). Small-intestinal transit time was 276.9 +/- 10.7 min (group A), 249.7 +/- 13.1 min (group B) and 245.6 +/- 11.6 min (group C) (P = 0.120). CL was the best tolerated preparation. Compliance with the bowel preparation regimen was lowest in group C (P = 0.008). CONCLUSIONS: A clear liquid diet and overnight fasting is sufficient to achieve an adequate level of cleanliness and is better tolerated by patients than other forms of preparation.

2010-12-31T23:00:00Z Borda-Martin, A. (Ana) Muñoz-Navas, M. (Miguel) Martinez-Peñuela, J.M. (J.M.) Jimenez, F.J. (F.J.) Carretero, C. (Cristina) Borda-Celaya, F. (F.) http://hdl.handle.net/10171/27489 2012-12-20T01:10:05Z 2008-12-31T23:00:00Z

Title: Estudio de las lesiones neoplásicas metacrónicas en el carcinoma colorrectal Author(s) : Borda-Martin, A. (Ana); Muñoz-Navas, M. (Miguel); Martinez-Peñuela, J.M. (J.M.); Jimenez, F.J. (F.J.); Carretero, C. (Cristina); Borda-Celaya, F. (F.) Abstract: Fundamento. Analizar la frecuencia y las características de las lesiones neoplásicas metacrónicas, carcinomas y adenomas, tras la resección de un cáncer colo-rectal (CCR). Pacientes y métodos. Revisamos 382 CCR operados y seguidos mediante colonoscopias completas en dos hospitales de nuestra comunidad. Analizamos las lesiones metacrónicas registradas valorando su localización, momento del diagnóstico, histología, número y tamaño. Estudiamos la frecuencia de adenomas de aparición precoz (12 meses), comparando su tamaño con respecto al resto de lesiones. Resultados. La mediana de seguimiento fue de 48 meses (12-112), con 2,74±1,47 colonoscopias/caso. Diagnosticamos 7 cánceres metacrónicos (1,8%), 4 de ellos en estadio I. La mediana de tiempo hasta su diagnóstico fue de 24 meses (13-54). Registramos adenomas metacrónicos en 162 casos (42,4%), sin diferencias entre los dos hospitales: 42,1% vs. 43,8% (p=0,88). Un 6,3% de los pacientes presentaron adenomas avanzados. En 164 casos en que el primer control se efectuó a los 12 meses, la incidencia de adenomas fue del 24%. Los adenomas fueron mayoritariamente únicos (60,8%) y menores de 5 mm (68,5%). En un 55,5% de los casos con pólipos, alguno tenía una localización proximal. El diagnóstico se realizó en la 1ª exploración (56,2%), 2ª (27,8%) ó 3ª (9%). La mediana de tiempo hasta el diagnóstico fue de 21 meses (12-112) para el adenoma simple y de 35 (12-112) para el avanzado. Conclusiones. Nuestro seguimiento permitió aplicar un tratamiento teóricamente curativo en la mayoría de los carcinomas metacrónicos diagnosticados. La alta incidencia de adenomas y su frecuente localización proximal hacen necesario un seguimiento con colonoscopias completas, que debería iniciarse al año de la operación y podría pasar a ser menos estricto tras tres exploraciones consecutivas sin pólipos.

2008-12-31T23:00:00Z Betes, M.T. (María Teresa) Muñoz-Navas, M. (Miguel) Duque, J.M. (José M.) Angos, R. (Ramón) Macias, E. (Elena) Subtil, J.C. (José Carlos) Herraiz, M. (Maite) Riva, S. (Susana) de la Delgado-Rodriguez, M. (Miguel) Martinez-Gonzalez, M.A. (Miguel Angel) http://hdl.handle.net/10171/27488 2012-12-20T01:14:51Z 2002-12-31T23:00:00Z

Title: Use of colonoscopy as a primary screening test for colorectal cancer in average risk people Author(s) : Betes, M.T. (María Teresa); Muñoz-Navas, M. (Miguel); Duque, J.M. (José M.); Angos, R. (Ramón); Macias, E. (Elena); Subtil, J.C. (José Carlos); Herraiz, M. (Maite); Riva, S. (Susana) de la; Delgado-Rodriguez, M. (Miguel); Martinez-Gonzalez, M.A. (Miguel Angel) Abstract: The use of colonoscopy as a primary screening test for colorectal cancer (CRC) in average risk adults is a subject of controversy. Our primary objective was to build a predictive model based on a few simple variables that could be used as a guide for identifying average risk adults more suitable for examination with colonoscopy as a primary screening test. METHODS: The prevalence of advanced adenomas was assessed by primary screening colonoscopy in 2210 consecutive adults at least 40 yr old, without known risk factors for CRC. Age, gender, and clinical and biochemical data were compared among people without adenomas, those with non-advanced adenomas, and those with any advanced neoplasm. A combined score to assess the risk of advanced adenomas was built with the variables selected by multiple logistic regression analysis. RESULTS: Neoplastic lesions were found in 617 subjects (27.9%), including 259 with at least one neoplasm that was 10 mm or larger, villous, or with moderate-to-severe dysplasia, and 11 with invasive cancers. Advanced lesions were more frequent among men, older people, and those with a higher body mass index (BMI). These three variables were independent predictors of advanced adenomas in multivariate analysis. A score combining age, sex, and BMI was developed as a guide for identifying individuals more suitable for screening colonoscopy. CONCLUSIONS: Age, gender, and BMI can be used to build a simple score to select those average risk adults who might be candidates for primary screening colonoscopy

2002-12-31T23:00:00Z