http://hdl.handle.net/10171/194 Sun, 26 May 2013 02:24:29 GMT 2013-05-26T02:24:29Z http://hdl.handle.net/10171/28188 Title: Design and evaluation of a treatment programme for Spanish adolescents with overweight and obesity. The EVASYON Study Author(s) : Martinez-Gomez, D. (David); Gomez-Martinez, S. (Sonia); Puertollano, M.A. (M. Ángeles); Nova, E. (Esther); Wärnberg, J. (Julia); Veiga, O.L. (Oscar L.); Marti, A. (Amelia); Campoy, C. (Cristina); Garagorri, J.M. (Jesús M.); Azcona, C. (Cristina); Vaquero, M.P. (M. Pilar); Redondo-Figuero, C. (Carlos); Delgado, M. (Manuel); Martinez, J.A. (José Alfredo); Garcia-Fuentes, M. (Miguel); Moreno, L.A. (Luis A.); Marcos, A. (Ascensión); EVASYON Study Group Abstract: Background The prevalence of overweight and obesity (OW/OB) among adolescents worldwide has increased since the 60 s. Spain has reached one of the highest OW/OB prevalence rates among adolescents from European countries. The aim of this methodological paper is to describe the design and evaluation in the EVASYON study (Development, implementation and evaluation of the efficacy of a therapeutic programme for adolescents with OW/OB: integral education on nutrition and physical activity). Methods/Design The EVASYON was planned by a multidisciplinary team to treat OW/OB in Spanish adolescents. The EVASYON is a multi-centre study conducted in 5 hospitals in 5 Spanish cities (Granada, Madrid, Pamplona, Santander and Zaragoza) and two hundred and four OW/OB Spanish adolescents were recruited for this intervention. The treatment was implemented for approximately one-year follow-up. The adolescents were treated in groups of a maximum of 10 subjects; each group had 20 visits during the treatment period in two phases: intensive during the first 2 months (1st to 9th visits), and extensive during the last 11 months (10th to 20th visits). In order to assess the efficacy of the treatment, 8 dimensions were measured: diet; physical activity and fitness; eating behaviour; body composition; haematological profile; metabolic profile; minerals and vitamins; immuno-inflammatory markers. Moreover, genetic polymorphisms were also determined. Discussion The treatment programme developed in the EVASYON study was designed as a national pilot study to be implemented as an effective treatment for adolescents with OW/OB into the Spanish Health Care Service. Wed, 31 Dec 2008 23:00:00 GMT http://hdl.handle.net/10171/28188 2008-12-31T23:00:00Z http://hdl.handle.net/10171/23070 Title: Design of the nutritional therapy for overweight and obese Spanish adolescents conducted by registered dieticians: the EVASYON study Author(s) : Marques, M. (María); Moleres, A. (Adriana); Rendo-Urteaga, T. (Tara); Gomez-Martinez, S. (S.); Zapatera, B. (B.); Romero, P. (P.); Miguel-Etayo, P. (P.) de; Campoy, C. (C.); Martinez, J.A. (José Alfredo); Azcona, C. (Cristina); Marcos, A. (A.); Marti, A. (Amelia); Warnberg, J. (J.) Abstract: Background: Dietary treatment for obese adolescents should aim to ensure adequate growth and development, by reducing excessive fat mass accumulation, avoiding loss of lean body mass, improving well-being and selfesteem and preventing cyclical weight regain. The aim of this article is to describe the dietary intervention design and the methods used to evaluate nutritional knowledge and behavior in the EVASYON study (Development, implementation and evaluation of the efficacy of a therapeutic programme for overweight/obese adolescents). Methods/design: EVASYON is a multi-centre study conducted in 5 Spanish hospital settings (Granada, Madrid, Pamplona, Santander and Zaragoza), where 204 overweight/obese Spanish adolescents were treated in groups of 9 to 11 subjects over 20 visits. The study was implemented in two stages: an intensive, calorie-restricted period for the first 9 weeks, and an extensive body-weight follow-up period for the last 11 months. A moderate energy intake restriction was applied in the intensive period according to the degree of obesity, on the basis of a balanced diet supplying 50-55% of daily energy as carbohydrates; 30-35% as fats and 10-15% as proteins. In the intensive period, adolescents were prescribed both a fixed full-day meal plan for the first three weeks and a full day meal plan with different food-choices for 6 weeks. Later, adolescents received a flexible meal plan based on food exchanges for the follow-up period until the end of the trial. Data on food intake, dietary and meal-related habits and behavior were collected by means of dietary questionnaires. To analyse nutritional knowledge, adolescents were examined regarding nutrient concepts and food items for a healthy diet with the appropriate tools. Participants were given nutritional information with complementary teaching material, which was available on the EVASYON website (www.estudioevasyon.com). Discussion: The dietary intervention of the EVASYON programme with a moderate calorie restriction for a limi - ted period of time could be a good strategy in treating overweight and obese adolescents and that will be tested further. Moreover, combining fixed plan with free-choice menus may help adolescents and their families to make right decisions for every day meals. Sat, 31 Dec 2011 23:00:00 GMT http://hdl.handle.net/10171/23070 2011-12-31T23:00:00Z http://hdl.handle.net/10171/22982 Title: Estilo comportamental al inicio del segundo año de vida:estudio retrospectivo en escolares afectados de trastorno por deficit de atencion e hiperactividad Author(s) : Magallon, S. (Sara); Crespo-Eguilaz, N. (Nerea); Ecay, M. (M.); Poch-Olive, M.L. (M.L.); Narbona, J. (Juan) Abstract: OBJECTIVES: To study the relationship between behavioural profile of children suffering from Attention Deficit Hyperactivity Disorder (ADHD) and the previous behavioural style of these patients as toddlers. SUBJECTS AND METHODS: We asked the parents of 50 schoolchildren with ADHD, and those of 30 controls, to fill in a Spanish version of the Toddler Behaviour Questionnaire (TBQ) from their retrospective perception of their children's behaviour as toddlers. TBQ items were grouped by factor analysis; t-Student between the scores of both groups and a multiple correlation analysis of TBQ and DSM-IV-ADHD-RS in each of the groups were used. RESULTS: Children in the ADHD group were reported by parents to have had a different toddler behavioural profile in comparison to that of control children (P<0.05). These differences were associated with adapting to new environments, mood, regularity and stability of play behaviour. A correlation was found between behavioural profile in DSM-IV-ADHD- RS and TBQ. CONCLUSIONS: The results of this study should be interpreted with caution. However, they suggest that in the fifth trimester of life a particular behavioural style as regards regularity, stability of play, and mood, could indicate a risk of developing ADHD in the future. This behavioural style should be taken into consideration in rearing and early education prospective studies. Wed, 31 Dec 2008 23:00:00 GMT http://hdl.handle.net/10171/22982 2008-12-31T23:00:00Z http://hdl.handle.net/10171/22921 Title: Síndrome de fatiga crónica en una adolescente de 15 años Author(s) : Diaz-Caneja, A. (A.); Rodriguez-Sosa, J.T. (J.T.); Aguilera-Albesa, S. (S.); Sanchez-Carpintero, R. (Rocío); Soutullo, C. (César) Abstract: Fatigue and lack of energy are frequent symptoms in children and adolescents. A diagnosis of chronic fatigue syndrome should be considered in children and adolescents who complain of chronic fatigue associated with other symptoms without a demonstrable physical cause. Lack of knowledge about this syndrome and late diagnosis may have a negative impact on the normal development of affected children and adolescents. Treatment should be based on a rehabilitation program with cognitive behavioral therapy and a gradual increase in activities. Sun, 31 Dec 2006 23:00:00 GMT http://hdl.handle.net/10171/22921 2006-12-31T23:00:00Z http://hdl.handle.net/10171/22860 Title: Estudio PET-TC con 18F-fluoro-L-DOPA combinado con el análisis genético para la optimización de la clasificación y tratamiento de un niño con hiperinsulinismo congénito grave Author(s) : Arbizu, J. (J.); Fernandez-Marmiesse, A. (A.); Garrastachu, P. (P.); Martino, E. (E.); Azcona-Sanjulian, M.C. (M.C.); Carracedo, A. (A.); Richter, J.A. (José Ángel) Abstract: Abstract BACKGROUND: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in infancy. The differential diagnosis between focal and diffuse forms of CHI is of great importance when planning surgery. The aim of this article is to show the first case of focal CHI diagnosed in Spain using PET-CT imaging combined with genetic analysis. METHODS: A 13 month child with CHI and normal conventional radiological investigations treated with diazoxide, diet control and feeding by gastrostomy is presented. Genetic analysis of ABCC8 and KCNJ11 genes and PET-TAC using 18F-fluoro-L-DOPA were performed. RESULTS: A pathological mutation (G111R) in the paternal allele of ABCC8 was detected. PET-CT scanning using 18F-fluoro-L-DOPA showed a focus of high uptake in the body of the pancreas compatible with adenoma that was hystopathologically confirmed. After surgical resection the patient is asymptomatic without needing either pharmacological treatment or dietetic control. CONCLUSIONS: The combination of genetic analysis and 18F-fluoro-L-DOPA PET-TAC shows a great potential for the identification, location and guideline for surgery in CHI. Wed, 31 Dec 2008 23:00:00 GMT http://hdl.handle.net/10171/22860 2008-12-31T23:00:00Z http://hdl.handle.net/10171/22859 Title: Alteraciones genéticas inducidas por los tratamientos antitumorales en pacientes pediátricos con cáncer: carcinogénesis química Author(s) : Patiño, A. (Ana); Lopez-de-la-Mesa, R. (R.); Sierrasesumaga, L. (Luis) Fri, 31 Dec 1999 23:00:00 GMT http://hdl.handle.net/10171/22859 1999-12-31T23:00:00Z http://hdl.handle.net/10171/22858 Title: Análisis de la implicación de los genes de supresión tumoral TP53, p16INK4, p21WAF1, RB1 y de las enzimas metabolizadoras de drogas en el desarrollo de tumores óseos en niños Author(s) : Patiño, A. (Ana); Sotillo, E. (Elena); Lopez-de-la-Mesa, R. (R.); Sierrasesumaga, L. (Luis) Abstract: Several tumor suppressor genes such as p16INK4, TP53, RB1 y p21WAF1 are involved in cell cycle regulation in response to DNA damage and belong to the complex pathway that regulates cell proliferation and/or differentiation. We have investigated the presence of mutations in those genes and polymorphisms of Drug Metabolizing Enzymes that could be involved in the development of pediatric bone tumors or in their outcome. MATERIALS AND METHODS: By means of PCR-based techniques, we have analyzed the presence of variations in the coding sequence of p16INK4, TP53, RB1 y p21WAF1 and of the Drug Metabolizing Enzymes in a group of 82 osteosarcomas and 47 Ewing's sarcomas as well as in a control group of 115 healthy children. RESULTS: We detected mutations of the TP53 gene in about 25% of the samples analyzed, most frequently in association with tumors of poor prognosis or reduced survival. The p16INK4 gene was homozygously deleted in 18% of the osteosarcomas, also associated with poor prognosis and unfavourable histologic subtypes; RB1 was altered in 21% of the osteosarcomas. We did not detect relevant associations between polymorphisms of the Drug Metabolizing Enzymes or mutation of the p21WAF1 and development of pediatric bone tumors. CONCLUSIONS: Alteration of TP53, p16INK4 and p21WAF1 seems to be involved in the development of pediatr Fri, 31 Dec 1999 23:00:00 GMT http://hdl.handle.net/10171/22858 1999-12-31T23:00:00Z http://hdl.handle.net/10171/19242 Title: Dietary total antioxidant capacity and obesity in children and adolescents Author(s) : Puchau, B. (Blanca); Ochoa, M.C. (María Carmen); Zulet, M.A. (María Ángeles); Marti, A. (Amelia); Martinez, J.A. (José Alfredo); Azcona, C. (Cristina); Martinez-Gonzalez, M.A. (Miguel Angel); Moreno-Aliaga, M.J. (María Jesús); Chueca, M. (M.); Oyarzabal, M. (M.); Patiño, A. (Ana) Abstract: Dietary antioxidant intake has been suggested to protect against oxidative damage and related clinical complications. The aim of this study was to assess the potential relationships between the dietary total antioxidant capacity (TAC) and obesity-related features in children and adolescents. Anthropometric variables from 369 children and adolescents were measured (184 obese and 185 control). A validated food-frequency questionnaire was used to calculate the TAC and the daily nutrient and energy intake. Dietary TAC showed positive associations with fiber, folic acid, magnesium, and vitamins A, C and E. BMI, SDS-BMI and total body fat were inversely associated with dietary TAC only in obese subjects. These data suggest that dietary TAC may be a potential indicator of the risk to develop obesity-related features and could be considered as a useful method in assessing antioxidant intake. Thu, 31 Dec 2009 23:00:00 GMT http://hdl.handle.net/10171/19242 2009-12-31T23:00:00Z