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PRDM16: The intercovertible adipo-myocyte switch
Authors: Frühbeck, G. (Gema)
Burrell, M.A. (M.A.)
Sesma, M.P. (María Pilar)
Keywords: Interconvertible
Adipo-myocyte
Switch
Issue Date: Apr-2009
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1016/j.tcb.2009.01.007
ISSN: 0962-8924
Citation: Fruhbeck G, Sesma P, Burrell MA. PRDM16: the interconvertible adipo-myocyte switch. Trends Cell Biol 2009 Apr;19(4):141-146.
Abstract
Both brown and white adipocytes were previously considered to be derived from the same precursor cell, despite being histologically and functionally different. However, a recent study shows that overexpression of the transcriptional regulator positive regulatory domain containing 16 (PRDM16) determines the development of brown adipocytes from a progenitor that expresses myoblast markers. Surprisingly, loss of PRDM16 from these precursors does not lead to white adipocyte differentiation. Thus, PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown adipocytes
Permanent link: http://hdl.handle.net/10171/12568
Appears in Collections:DA - Medicina - Endocrinología - Artículos de revista
DA - CUN - Endocrinología y Nutrición - Artículos de revista
DA - CIFA - Laboratorio de investigación metabólica - Artículos de Revista
DA - Ciencias - HAP - Artículos de revista

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