Dadun/></a>
				</td>
				<td class= Dadun
   (New user)
Help  | Contact  |  Castellano English  
 

Dadun > Depósito Académico > Facultad de Ciencias > Departamento de Histología y Anatomía Patológica > DA - Ciencias - HAP - Artículos de revista >

A gene-alteration profile of human lung cancer cell lines
Authors: Blanco, R. (R.)
Iwakawa, R. (R.)
Tang, M. (Moying)
Kohno, T. (Takashi)
Angulo, B. (B.)
Pio, R. (Rubén)
Montuenga, L.M. (Luis M.)
Minna, J.D. (John D.)
Yokota, J. (Jun)
Sanchez-Cespedes, M. (Montserrat)
Keywords: Lung cancer
Oncogenes
Tumor suppressors
Tyrosine kinase inhibitors
Issue Date: 12-Mar-2009
Publisher: Human Mutation
Publisher version: http://dx.doi.org/10.1002/humu.21028
ISSN: 1059-7794
Citation: Blanco R, Iwakawa R, Tang M, Kohno T, Angulo B, Pio R, et al. A gene-alteration profile of human lung cancer cell lines. Hum Mutat 2009 Aug;30(8):1199-1206.
Abstract
ABSTRACT: Aberrant proteins encoded from genes altered in tumors drive cancer development and may also be therapeutic targets. Here we derived a comprehensive gene-alteration profile of lung cancer cell lines. We tested 17 genes in a panel of 88 lung cancer cell lines and found the rates of alteration to be higher than previously thought. Nearly all cells feature inactivation at TP53 and CDKN2A or RB1, whereas BRAF, MET, ERBB2, and NRAS alterations were infrequent. A preferential accumulation of alterations among histopathological types and a mutually exclusive occurrence of alterations of CDKN2A and RB1 as well as of KRAS, epidermal growth factor receptor (EGFR), NRAS, and ERBB2 were seen. Moreover, in nonsmall- cell lung cancer (NSCLC), concomitant activation of signal transduction pathways known to converge in mammalian target of rapamycin (mTOR) was common. Cells with single activation of ERBB2, PTEN, or MET signaling showed greater sensitivity to cell-growth inhibition induced by erlotinib, LY294002, and PHA665752, respectively, than did cells featuring simultaneous activation of these pathways, underlining the need for combined therapeutic strategies in targeted cancer treatments. In conclusion, our gene-alteration landscape of lung cancer cell lines provides insights into how gene alterations accumulate and biological pathways interact in cancer. Hum Mutat 30, 1199–1206, 2009. & 2009Wiley-Liss, Inc.
Permanent link: http://hdl.handle.net/10171/13568
Appears in Collections:DA - CIMA - Oncología - Biomarcadores - Artículos de Revista
DA - Ciencias - HAP - Artículos de revista

Files in This Item:
File:  montuengaagenealteration2009.pdf
Description: 
Size:  313,51 kB
Format:  Adobe PDF
 View / Open 

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.