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Evidences on three relevant obesogenes: MC4R, FTO and PPARγ. Approaches for personalized nutrition.
Authors: Razquin, C. (Cristina)
Marti, A. (Amelia)
Martinez, J.A. (José Alfredo)
Keywords: Obesity
Candidate gene
Gene variant
Nutrigenetics
Physical activity
Pharmacogenetics
Obesidad
Nutrigenómica
Genética
Nutrición y dietética
Issue Date: Jan-2011
Publisher: Wiley Blackwell
Publisher version: http://dx.doi.org/10.1002/mnfr.201000445
ISSN: 1613-4125
Citation: Razquin C, Marti A, Martinez JA. Evidences on three relevant obesogenes: MC4R, FTO and PPARgamma. Approaches for personalized nutrition. Mol Nutr Food Res 2011 Jan;55(1):136-149.
Abstract
Obesity is a complex disease that results from the interaction between lifestyle (dietary patterns and sedentary habits) and genetic factors. The recognition of a genetic basis for human obesity have driven to identify putative causal genes to understand the pathways that control body mass and fat deposition in humans as well as to provide personalized treatments and prevention strategies to fight against obesity. More than 120 candidate genes have been associated with obesity-related traits. GWAS (genome-wide association study) have so far identified over 20 novel loci convincingly associated with adiposity. This review is specifically focused on the study of the effects of MC4R, PPARγ and FTO gene variants and their interactions with dietary intake, physical activity or drug administration on body weight control. The advances in this field are expected to open new ways in genome-customized diets for obesity prevention and therapy following personalized approaches. 2
Permanent link: http://hdl.handle.net/10171/16312
Appears in Collections:DA - Farmacia - CAFT - Línea Especial de Nutrición
DA - Farmacia - CAFT - Artículos de revista

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