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Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation
Authors: Cuadrado-Tejedor, M. (Mar)
Ricobaraza, A. (Ana)
Rio, J. (Joaquín) del
Frechilla, D. (Diana)
Franco, R. (Rafael)
Perez-Mediavilla, L.A. (Luis Alberto)
Garcia-Osta, A. (Ana)
Keywords: Alzheimer’s disease
Hippocampus andcognitiveimpairment
Issue Date: Jun-2011
Publisher: Elsevier
Publisher version:
ISSN: 0166-4328
Citation: Cuadrado-Tejedor M, Ricobaraza A, Del Rio J, Frechilla D, Franco R, Perez-Mediavilla A, et al. Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation. Behav Brain Res 2011 Jul 7;220(2):338-343.
This studywasundertakentoknowwhethercognitiondeficitsproducedbychronicmildstress(CMS) were associatedwithpathologicalmarkersofAlzheimer’sdisease(AD).Theresultsshowthattheimpair- ment intheMorriswatermazetestinducedbyCMScorrelatedwithanincreaseinCDK5-dependent phospho-tau levelsandwithanincreaseinAPPprocessing.MiceexposedtoCMSmaythenconstitutea non-transgenic modelforsporadicformsofAD
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Appears in Collections:DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista
DA - Ciencias - HAP - Artículos de revista
DA - Ciencias - Bioquímica y Biología molecular - Artículos de Revista

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