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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Terapia celular > DA - CIMA - Oncología - Terapia celular - Artículos de Revista >

Stem Cells to Regenerate Cardiac Tissue in Heart Failure
Authors: Prosper, F. (Felipe)
Herreros, J. (Jesús)
Alegria, E. (Eduardo)
Keywords: Heart failure
Stem cells
Myoblasts
Cardiac regeneration
Transdifferentiation
Issue Date: 2003
Publisher: Doyma
ISSN: 0300-8932
Citation: Prósper, F., Herreros, J. Alegría, E. Rev Esp Cardiol 2003; 56(10): 935-9
Abstract
Myocardial regeneration is one of the most promising therapeutic strategies for heart failure patients. Many experimental studies have demonstrated that different types of stem cell can differentiate into myocardial cells and tissues necessary for regeneration of the damaged myocardium, while studies in experimental animals suggest that muscle (myoblast), bone marrow (mesenchymal, endothelial or hematopoietic progenitors) and even heart cells can help to improve heart contractility in vivo. These findings have led several groups to undertake studies in patients with myocardial infarction. However, the use of cellular therapy in clinical trials is not without controversy, mainly related with the need for better knowledge before these therapeutic strategies are used in clinical practice. Although significant enhancement of our knowledge of the processes involved is fundamental, we do not consider it unreasonable to initiate clinical trials in which specific questions are posed, whose answers will allow us to make further progress.
Permanent link: http://hdl.handle.net/10171/17242
Appears in Collections:DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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