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Dadun > Depósito Académico > Facultad de Farmacia > Departamento de Ciencias de la Alimentación, Fisiología y Toxicología > DA - Farmacia - CAFT - Artículos de revista >

Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a beta(3)-adrenergic agonist and lack of effect of leptin.
Authors: Gomez-Ambrosi, J. (Javier)
Frühbeck, G. (Gema)
Martinez, J.A. (José Alfredo)
Keywords: PGC-1
PPARγ2
β3-adrenergic agonist
Uncoupling protein
Brown adipose tissue
Rat
Issue Date: 2001
Publisher: Elsevier
Publisher version: doi:10.1016/S0303-7207(01)00451-8
ISSN: 0303-7207
Citation: Gomez-Ambrosi J, Fruhbeck G, Martinez JA. Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a beta(3)-adrenergic agonist and lack of effect of leptin. Mol Cell Endocrinol 2001 May 15;176(1-2):85-90.
Abstract
Peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) is highly expressed in brown adipose tissue (BAT) and plays an important role in adaptive thermogenesis. The aim of this study was to assess the acute effect of a β3-adrenergic agonist (Trecadrine) and leptin on the expression of PGC-1 and PPARγ2 mRNA in BAT. Trecadrine produced a marked increase (4.5-fold) in PGC-1 mRNA compared to controls (P<0.001) without changes in PPARγ2 mRNA, whereas leptin administration did not alter either PGC-1 or PPARγ2 expression. These results show that selective stimulation of the β3-adrenoceptor rapidly upregulates the expression of PGC-1 in brown adipocytes without a concomitant increase in PPARγ2. Moreover, our results show that PGC-1 and PPARγ2 expression in BAT seems not to be acutely regulated by leptin.
Permanent link: http://hdl.handle.net/10171/17500
Appears in Collections:DA - Medicina - Endocrinología - Artículos de revista
DA - CUN - Endocrinología y Nutrición - Artículos de revista
DA - CIFA - Laboratorio de investigación metabólica - Artículos de Revista
DA - Farmacia - CAFT - Artículos de revista

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