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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Terapia celular > DA - CIMA - Oncología - Terapia celular - Artículos de Revista >

Identification of c-Kit gene mutations in patients with polycythemia vera
Authors: Fontalba, A. (A.)
Real, P.J. (Pedro J.)
Fernandez-Luna, J.L. (J. L.)
Aguirre, X. (Xavier)
Prosper, F. (Felipe)
Richard, C. (Carlos)
Keywords: C-Kit
Polycythemia
Vera
Mutation
Issue Date: 2006
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/journal/01452126
ISSN: 0145-2126
Citation: Fontalba, A., Real P. J., Fernández-Luna, J. L., Agirre, X. et al. Leukemia Research. 2006; 30: 1323–1326
Abstract
Imatinib mesylate has recently been reported to have clinical activity in the treatment of polycythemia vera (PV), suggesting the involvement of one of the kinases targeted by this inhibitor, including c-Kit and PDGFR. Activating c-Kit mutations have been identified in patients with mastocytosis and other myeloid disorders such as acute myeloid leukemia. Thus, we wanted to analyze the presence of mutations of c-Kit in polycythemia vera patients. We found that 7 out of 20 patients carried missense mutations in the c-Kit gene whereas no sequence variation was detected in 15 healthy controls.
Permanent link: http://hdl.handle.net/10171/17548
Appears in Collections:DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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