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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Terapia celular > DA - CIMA - Oncología - Terapia celular - Artículos de Revista >

Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia
Authors: Roman-Gomez, J. (José)
Jimenez-Velasco, A. (A.)
Aguirre, X. (Xavier)
Castillejo, J.A. (J.A.)
Navarro, G. (Germán)
San-Jose, E. (Edurne)
Garate, L. (Leire)
Cordeu, L. (Lucía)
Cervantes, F. (F.)
Prosper, F. (Felipe)
Heiniger, A. (A.)
Torres, A. (Antonio)
Keywords: Cancer testis antigens
HAGE
Hypomethylation
CML
Issue Date: 2007
Publisher: Pensiero Scientifico / Ferrata Storti Foundation
ISSN: 0390-6078
Citation: Román-Gómez, J., Jiménez-Velasco, A., Agirre, X., Castillejo, J. A. et al... Haematologica 2007; 92: 153-162
Abstract
Cancer testis antigens (CTA) provide attractive targets for cancer-specific immunotherapy. Although CTA genes are expressed in some normal tissues, such as the testis, this immunologically protected site lacks MHC I expression and as such, does not present self antigens to T cells. To date, CTA genes have been shown to be expressed in a range of solid tumors via demethylation of their promoter CpG islands, but rarely in chronic myeloid leukemia (CML) or other hematologic malignancies.
Permanent link: http://hdl.handle.net/10171/17646
Appears in Collections:DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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