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Please use this identifier to cite or link to this item:
http://hdl.handle.net/10171/17786
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| Title: | TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle. |
| Author(s) : | Marti, A. (Amelia)
Corbalan, M. (M.S.)
Martinez-Gonzalez, M.A. (Miguel Angel)
Martinez, J.A. (José Alfredo) |
| Issue Date: | 2002 |
| Publisher: | Wiley Blackwell. The definitive version is available at www3.interscience.wiley.com |
| Citation: | Marti A, Corbalan MS, Martinez-Gonzalez MA, Martinez JA. TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle. Diabetes Obes Metab 2002 Nov;4(6):428-430. |
| Keywords: | β3-adrenergic receptor
Case–control study
Recreational energy expenditure
Obesity
Trp64Arg mutation |
| Abstract: | Aim: We performed a case–control study to assess the association between obesity risk and the Trp64Arg polymorphism of the β3-adrenergic receptor gene.
Methods: Obese subjects [n = 159; body mass index (BMI) > 30 kg/m2] and controls (n = 154; BMI < 25 kg/m2) were compared using multivariable logistic regression to control for potential confounders.
Results: A higher obesity risk (adjusted OR: 2.98; 95% CI: 1.00–8.56; p = 0.05) was associated with the Trp64Arg polymorphism among sedentary, but not among more active people.
Conclusions: Our results suggest that the TRP64ARG polymorphism of the ADRB3 seems to be a risk factor for obesity that is dependent on a sedentary lifestyle. |
| URI: | http://hdl.handle.net/10171/17786 |
| Publisher version (URL): | http://bit.ly/fvLc2q |
| Appears in Collections: | DA - Medicina - MPSP -Artículos de revista
DA - Farmacia - CAFT - Artículos de revista
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