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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Enfermedad vascular hipertensiva > DA - CIMA - Cardiovasculares - Enfermedad vascular - Artículos de Revista >

Preliminary characterisation of the promoter of the human p22phox gene: identification of a new polymorphism associated with hypertension
Authors: Moreno, M.U. (María Ujué)
San-Jose, G. (Gorka)
Orbe, J. (Josune)
Paramo, J.A. (José Antonio)
Beloqui, O. (Óscar)
Diez, J. (Javier)
Zalba, G. (Guillermo)
Keywords: Hypertension
NAD(P)H oxidase
Polymorphism
Promoter
Issue Date: 2003
Publisher: Elsevier Science B.V
Publisher version: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T36-48B0K9M-5&_user=766132&_coverDate=05%2F08%2F2003&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000042418&_version=1&_urlVersion=0&_userid=766132&md5=2a2d3c4aedf5064a8dbfac75990c3007&searchtype=a
ISSN: 1873-3468
Citation: Moreno MU, San José G, Orbe J, Páramo JA, Beloqui O, Díez J, et al. Preliminary characterisation of the promoter of the human p(22phox) gene: identification of a new polymorphism associated with hypertension. FEBS Lett 2003 MAY 8;542(1-3):27-31.
Abstract
The p22(phox) subunit is an essential protein in the activation of NAD(P)H oxidase. Here we report the preliminary characterisation of the human p22(phox) gene promoter. The p22(phox) promoter contains TATA and CCAC boxes and Sp1, gamma-interferon and nuclear factor kappaB sites. We screened for mutations in the p22(phox) promoter and identified a new polymorphism, localised at position -930 from the ATG codon, which was associated with hypertension. Mutagenesis experiments showed that the G allele had higher promoter activity than the A allele. These results suggest that the -930(A/G) polymorphism in the p22(phox) promoter may be a novel genetic marker associated with hypertension.
Permanent link: http://hdl.handle.net/10171/17837
Appears in Collections:DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista
DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista
DA - CIMA - Cardiovasculares - Enfermedad vascular - Artículos de Revista

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