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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Imagen del cáncer > DA - CIMA - Oncología - Imagen del cáncer - Comunicaciones a congresos, Conferencias... >

Automated Quantitative Analysis of a Mouse Model of Chronic Pulmonary Inflammation using Micro X-ray Computed Tomography
Authors: Artaechevarria-Artieda, X. (Xabier)
Perez-Martin, D. (Daniel)
Reinhardt, J.M. (Joseph M.)
Muñoz-Barrutia, A. (Arrate)
Ortiz-de-Solorzano, C. (Carlos)
Keywords: Tomography
Lung neoplasm
Lung diseases
Issue Date: 2-May-2011
Publisher version: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.148.5532
Abstract
Micro-CT has emerged as an excellent tool for in-vivo imaging of the lungs of small laboratory animals. Several studies have shown that it can be used to assess the evolution of pulmonary lung diseases in longitudinal studies. However, most of them rely on non-automatic tools for image analysis, or are merely qualitative. In this article, we present a longitudinal, quantitative study of a mouse model of silica-induced pulmonary inflammation. To automatically assess disease progression, we have devised and validated a lung segmentation method that combines threshold-based segmentation, atlas-based segmentation and level sets. Our volume measurements, based on the automatic segmentations, point at a compensation mechanism which leads to an increase of the healthy lung volume in response to the loss of functional tissue caused by inflammation.
Permanent link: http://hdl.handle.net/10171/17853
Appears in Collections:DA - CIMA - Unidad de Imagen - Comunicaciones a congresos, Conferencias ...
DA - CIMA - Oncología - Imagen del cáncer - Comunicaciones a congresos, Conferencias...

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