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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Oncología molecular > DA - CIMA - Oncología - Oncología molecular - Artículos de Revista >

Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon alpha
Authors: Alizadeh, A.A. (Ash A.)
Bohen, S.P. (S.P.)
Lossos, C. (Chen)
Martinez-Climent, J.A. (José Angel)
Ramos, J.C. (Juan Carlos)
Cubedo, E. (Elena)
Harrington, W. (W.J.)
Lossos, I.S. (Izidore S.)
Keywords: Chemotherapeutic approaches
Lymphoid leukemia
Prognostication
Transcription factor changes
Issue Date: 2010
Publisher: Informa Healthcare
Publisher version: http://informahealthcare.com/doi/abs/10.3109/10428191003728628
ISSN: 1029-2403
Citation: Alizadeh AA, Bohen SP, Lossos C, Martinez-Climent JA, Ramos JC, Cubedo-Gil E, et al. Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon alpha. Leuk Lymphoma 2010 Jul;51(7):1200-1216.
Abstract
Adult T-cell leukemia-lymphoma (ATLL) is an HTLV-1-associated lymphoproliferative malignancy that is frequently fatal. We compared gene expression profiles (GEPs) of leukemic specimens from nine patients with ATLL at the time of diagnosis and immediately after combination therapy with zidovudine (AZT) and interferon alpha (IFNalpha). GEPs were also related to genetic aberrations determined by comparative genomic hybridization. We identified several genes anomalously over-expressed in the ATLL leukemic cells at the mRNA level, including LYN, CSPG2, and LMO2, and confirmed LMO2 expression in ATLL cells at the protein level. In vivo AZT-IFNalpha therapy evoked a marked induction of interferon-induced genes accompanied by repression of cell-cycle regulated genes, including those encoding ribosomal proteins. Remarkably, patients not responding to AZT-IFNalpha differed most from responding patients in lower expression of these same IFN-responsive genes, as well as components of the antigen processing and presentation apparatus. Demonstration of specific gene expression signatures associated with response to AZT-IFNalpha therapy may provide novel insights into the mechanisms of action in ATLL.
Permanent link: http://hdl.handle.net/10171/17887
Appears in Collections:DA - CIMA - Oncología - Oncología molecular - Artículos de Revista

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