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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Oncología molecular > DA - CIMA - Oncología - Oncología molecular - Artículos de Revista >

Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis
Authors: Kwek, S.S. (S. S.)
Roy, R. (R.)
Zhou, H. (H.)
Climent, J. (J.)
Martinez-Climent, J.A. (José Angel)
Fridlyand, J. (J.)
Albertson, D. (Donna G.)
Keywords: Gene amplification
Array CGH
Breast cancer
8p12
11q13
CCND1
Issue Date: 2009
Publisher: Nature Publishing Group
Publisher version: http://www.nature.com/onc/journal/v28/n17/full/onc200934a.html
ISSN: 1476-5594
Citation: Kwek SS, Roy R, Zhou H, Climent J, Martinez-Climent JA, Fridlyand J, et al. Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis. Oncogene 2009 Apr 30;28(17):1892-1903.
Abstract
Co-amplification at chromosomes 8p11-8p12 and 11q12-11q14 occurs often in breast tumors, suggesting possible cooperation between genes in these regions in oncogenesis. We used high-resolution array comparative genomic hybridization (array CGH) to map the minimal amplified regions. The 8p and 11q amplicons are complex and consist of at least four amplicon cores at each site. Candidate oncogenes mapping to these regions were identified by combining copy number and RNA and protein expression analyses. These studies also suggested that CCND1 at 11q13 induced expression of ZNF703 mapping at 8p12, which was subsequently shown to be mediated by the Rb/E2F pathway. Nine candidate oncogenes from 8p12 and four from 11q13 were further evaluated for oncogenic function. None of the genes individually promoted colony formation in soft agar or collaborated with each other functionally. On the other hand, FGFR1 and DDHD2 at 8p12 cooperated functionally with MYC, whereas CCND1 and ZNF703 cooperated with a dominant negative form of TP53. These observations highlight the complexity and functional consequences of the genomic rearrangements that occur in these breast cancer amplicons, including transcriptional cross-talk between genes in the 8p and 11q amplicons, as well as their cooperation with major pathways of tumorigenesis.
Permanent link: http://hdl.handle.net/10171/17891
Appears in Collections:DA - CIMA - Oncología - Oncología molecular - Artículos de Revista

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