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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Terapia celular > DA - CIMA - Oncología - Terapia celular - Artículos de Revista >

Comparison of ex vivo expansion culture conditions of mesenchymal stem cells for human cell therapy
Authors: Perez-Ilzarbe, M. (Maitane)
Diez-Campelo, M. (M.)
Aranda, P. (P.)
Tabera, S. (Soraya)
Lopez, T. (Tania)
Cañizo, C. (C.) del
Merino, J. (Juana)
Moreno, C. (Cristina)
Andreu, E.J. (Enrique José)
Prosper, F. (Felipe)
Perez-Simon, J.A. (José Antonio)
Keywords: Materias Investigacion::Ciencias de la Salud::Oncología
Issue Date: 2009
Publisher: Wiley-Blackwell
Publisher version: doi: 10.1111/j.1537-2995.2009.02226.x
ISSN: 0041-1132
Citation: Perez-Ilzarbe, M., Diez-Campelo, M., Aranda, P., Tabera, S. et al. Comparison of ex vivo expansion culture conditions of mesenchymal stem cells for human cell therapy.Transfusion 2009; 49 (9): 1901–1910
Abstract
Mesenchymal stem cells (MSCs) are multipotent stem cells. Based on their properties, several clinical trials have been designed to explore their potential therapeutic effect. Fetal calf serum (FCS, commonly used for in vitro expansion) is an undesirable source of xenogeneic antigens and bears the risk of transmitting contaminations. As an alternative for FCS, platelet lysate (PL) and both autologous and allogeneic human serum have been proposed. The aim of this study is to compare the culture of bone marrow (BM)- derived MSCs in the presence of different serum supplements to determine the effect on cell growth, differentiation potential, and immunologic function.
Permanent link: http://hdl.handle.net/10171/18023
Appears in Collections:DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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