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Please use this identifier to cite or link to this item:
http://hdl.handle.net/10171/18023
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| Title: | Comparison of ex vivo expansion culture conditions of mesenchymal stem cells for human cell therapy |
| Author(s) : | Perez-Ilzarbe, M. (Maitane)
Diez-Campelo, M. (M.)
Aranda, P. (P.)
Tabera, S. (Soraya)
Lopez, T. (Tania)
Cañizo, C. (C.) del
Merino, J. (Juana)
Moreno, C. (Cristina)
Andreu, E.J. (E.J.)
Prosper, F. (Felipe)
Perez-Simon, J.A. (José Antonio) |
| Issue Date: | 2009 |
| Publisher: | Wiley-Blackwell |
| Citation: | Perez-Ilzarbe, M., Diez-Campelo, M., Aranda, P., Tabera, S. et al. Comparison of ex vivo expansion culture conditions of mesenchymal stem cells for human cell therapy.Transfusion 2009; 49 (9): 1901–1910 |
| Keywords: | Materias Investigacion::Ciencias de la Salud::Oncología |
| Abstract: | Mesenchymal stem cells (MSCs) are
multipotent stem cells. Based on their properties,
several clinical trials have been designed to explore
their potential therapeutic effect. Fetal calf serum (FCS,
commonly used for in vitro expansion) is an undesirable
source of xenogeneic antigens and bears the risk of
transmitting contaminations. As an alternative for FCS,
platelet lysate (PL) and both autologous and allogeneic
human serum have been proposed. The aim of this
study is to compare the culture of bone marrow (BM)-
derived MSCs in the presence of different serum
supplements to determine the effect on cell growth, differentiation
potential, and immunologic function. |
| URI: | http://hdl.handle.net/10171/18023 |
| Publisher version (URL): | doi: 10.1111/j.1537-2995.2009.02226.x |
| Appears in Collections: | DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista
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