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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Terapia celular > DA - CIMA - Oncología - Terapia celular - Artículos de Revista >

Isolation, culture and characterization of adult carotid body-derived cells
Authors: Izal-Azcarate, A. (A.)
Gutierrez-Perez, M. (María)
Izal, I. (I.)
Belzunegui, S. (S.)
San-Sebastian, W. (Waldy)
Lopez, B. (Berta)
Marcilla, I. (Irene)
Prosper, F. (Felipe)
Luquin, M.R. (María Rosario)
Keywords: Carotid body cells
Cell theraphy
Parkinson disease
Issue Date: 2009
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1016/j.resp.2009.04.021
ISSN: 1569-9048
Citation: Izal-Azcarate, A., Gutierrez-Perez, M., Izal, I., Belzunegui, S. et al.Isolation, culture and characterization of adult carotid body-derived cells. Respiratory Physiology & Neurobiology (2009); 167: 201–207
Abstract
Recent studies indicate that carotid body (CB) could be a suitable cell source for cell therapy in Parkinson’s disease.We have isolated and successfully expanded in culture as monolayer adult CB-derived cells using a modification of the culture medium employed for bone marrow multipotent adult progenitor cells (MAPCs). These cells express variable amounts of tyrosine hydroxylase (TH), -III tubulin and Sox2. In addition, CB-derived cells showed high expression of Sox2 related to a high rate of proliferation and consistent with an undifferentiated state. Under culture conditions that reduced cell proliferation, Sox2 expression decreased while TH and -III tubulin expression was increased. This could indicate that the differentiation of some cells occurs in the culture, thus accounting for a certain neural differentiation potential of CB-derived cells.
Permanent link: http://hdl.handle.net/10171/18024
Appears in Collections:DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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