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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Terapia celular > DA - CIMA - Oncología - Terapia celular - Artículos de Revista >

Adult Stem Cells: From New Cell Sources to Changes in Methodology
Authors: Pelacho, B. (Beatriz)
Mazo, M. (Manuel)
Gavira, J.J. (Juan José)
Prosper, F. (Felipe)
Keywords: Stem cell therapy
Trophic mechanisms
Cardiac patches
Bioartificial hearts
Cardiovascular diseases
Issue Date: 2010
Publisher: Springer Verlag
Publisher version: http://dx.doi.org/10.1007/s12265-010-9245-z
ISSN: 1937-5387
Citation: Pelacho, B, Mazo, M, Gavira, JJ, Prosper, F. Adult Stem Cells: From New Cell Sources to Changes in Methodology. J of Cardiovasc. Trans. Res. 2010; 4 (2): 154-160.
Abstract
Cardiovascular diseases constitute the first cause of mortality and morbidity worldwide. Alternative treatments like transplantation of (stem) cell populations derived from several adult tissue sources, like the bone marrow, skeletal muscle, or even adipose tissue, have been already employed in diverse clinical trials. Results from these studies and previous animal studies have reached to the conclusion that stem cells induce a benefit in the treated hearts, which is exerted mainly through paracrine mechanisms and not through direct differentiation as it was initially expected. However, a strong technical limitation for the stem cell therapy, which is the low level of cell survival and engraftment, diminishes their potential. Thus, new strategies like combination of the cells with bioengineering techniques have been developed and are being subject of intense research, suggesting that new strategies may improve the efficacy of these therapies. In this review, we will discuss the different therapeutic approaches, drawbacks, and future expectations of new regenerative therapies for cardiovascular diseases.
Permanent link: http://hdl.handle.net/10171/18288
Appears in Collections:DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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