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Dadun > Depósito Académico > Facultad de Farmacia > Departamento de Ciencias de la Alimentación, Fisiología y Toxicología > DA - Farmacia - CAFT - Artículos de revista >

Effects of different protein content and glycemic index of ad libitum diets on diabetes risk factors in overweight adults: the DIOGenes multicentre, randomised, dietary intervention trial.
Authors: Goyenechea, E. (Estíbaliz)
Holst, C. (C.)
Saris, W.H. (W.H.)
Jebb, S.A. (Susan A.)
Kafatos, A. (A.)
Handjiev, S. (S.)
Hlavaty, P. (P.)
Stender, S. (Steen)
Larsen, T.M. (Thomas M.)
Astrup, A. (A.)
Martinez, J.A. (José Alfredo)
Keywords: Obesity
Diabetes
Insulin resistance
High-protein diets
Low-glycemic index diets
Energy restriction
Weight loss
Issue Date: 2011
Publisher: Wiley Blackwell
Publisher version: http://dx.doi.org/10.1002/dmrr.1218
ISSN: 1520-7552
Citation: Goyenechea E, Holst C, Saris WH, Jebb S, Kafatos A, Pfeiffer A, et al. Effects of different protein content and glycemic index of ad libitum diets on diabetes risk factors in overweight adults: the DIOGenes multicentre, randomised, dietary intervention trial. Diabetes Metab Res Rev 2011 May 17.
Abstract
Aims/hypothesis: Diets with different amounts of protein and glycemic index (GI) may be of importance in the control of body weight and metabolic consequences, especially those related to insulin sensitivity. Methods: In DIOGenes, overweight/obese adults in 8 European countries who lost ≥ 8% of initial body-weight (BW) after following a low calorie diet (LCD) were later randomly assigned into five ad libitum interventional groups during 6 months: Low Protein [LP]/Low GI [LGI]; LP/High GI [HGI]; High Protein [HP]/LGI; HP/HGI and a healthy control diet. BW, fasting plasma glucose and insulin as well as an oral glucose tolerance test (OGTT), HOMA-IR, adiponectin and fructosamine levels were determined at the three time points. Results: The LCD period was initiated by 932 adults, 773 were randomised to the 5 diets and 548 completed the intervention. The HP and LGI diets were related to weight-loss management (p<0.05). The LP/HGI diet induced a higher HOMA-IR increase during the 6 months period. The HP and LGI diets were related to decreasing HOMA-IR changes in those patients with the highest weight-loss (≥10% of initial body-weight). The LGI diet also lead to a decrease in fructosamine levels during the intervention (p<0.05). Plasma insulin response was lower in the HP/LGI after 60 and 90min of the beginning of the OGTT at the end of the 6-months intervention (p<0.05). Conclusion/Interpretation: An increase in dietary protein and a reduction in GI content over a 6-month ad libitum dietary intervention are related to a lower drop-out rate and Accepted Article 4 produced favorable effects on glycaemic control and insulin sensitivity in overweight/obese subjects after an initial body-weight loss. The study was registered with ClinicalTrials.gov, number NCT00390637.
Permanent link: http://hdl.handle.net/10171/18292
Appears in Collections:DA - Farmacia - CAFT - Línea Especial de Nutrición
DA - Farmacia - CAFT - Artículos de revista

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