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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Terapia celular > DA - CIMA - Oncología - Terapia celular - Artículos de Revista >

Poor prognosis in acute lymphoblastic leukemia may relate to promoter hypermethylation of cancer-related genes
Authors: Roman-Gomez, J. (José)
Jimenez-Velasco, A. (A.)
Barrios, M. (M.)
Prosper, F. (Felipe)
Heiniger, A. (A.)
Torres, A. (Antonio)
Aguirre, X. (Xavier)
Keywords: Acute lymphoblastic leukemia
Methylation
Prognosis
Issue Date: 2007
Publisher: Informa Healthcare
Publisher version: http://dx.doi.org/10.1080/10428190701344899
ISSN: 1042-8194
Citation: Roman-Gomez, J., Jimenez-Velasco, A., Barrios, M., Prosper, F. et al. Poor prognosis in acute lymphoblastic leukemia may relate to promoter hypermethylation of cancer-related genes. Leuk. Lymphoma 2007; 48 (7): 1269–1282
Abstract
The hallmark of acute lymphoblastic leukemia (ALL) is a progressive appearance of malignant cell behavior that is triggered by the evolution of altered gene function. ALL has traditionally been viewed as a genetic disease; however, epigenetic defects also play an important role. DNA promoter methylation has gained increasing recognition as an important mechanism for transcriptional silencing of tumor-suppressor genes. Hypermethylation may contribute to the pathogenesis of leukemias providing an alternative route to gene mutation. We have reported that gene methylation in ALL cells is the most important way to inactivate cancer-related genes in this disease. In fact, this epigenetic event can help to inactivate tumor-suppressive apoptotic or growth-arresting responses and has prognostic impact in B- and T-ALL. The presence in individual tumors of multiple genes simultaneously methylated is an independent factor of poor prognosis in both childhood and adult ALL in terms of disease-free survival and overall survival. Moreover, methylation status is able to redefine the prognosis of selected ALL groups with well-established prognostic features.
Permanent link: http://hdl.handle.net/10171/18351
Appears in Collections:DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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