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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Terapia celular > DA - CIMA - Oncología - Terapia celular - Artículos de Revista >

Methylation status of Wnt signaling pathway genes affects the clinical outcome of Philadelphia-positive acute lymphoblastic leukemia
Authors: Martin, V. (Vanesa)
Aguirre, X. (Xavier)
Jimenez-Velasco, A. (A.)
San-Jose, E. (Edurne)
Cordeu, L. (Lucía)
Garate, L. (Leire)
Vilas, A. (Amaia)
Castillejo, J.A. (J.A.)
Heiniger, A. (A.)
Prosper, F. (Felipe)
Torres, A. (Antonio)
Roman-Gomez, J. (José)
Keywords: Materias Investigacion::Ciencias de la Salud::Oncología
Issue Date: 2008
Publisher: Wiley-Blackwell
Publisher version: http://dx.doi.org/10.1111/j.1349-7006.2008.00884.x
ISSN: 1347-9032
Citation: Martin, V., Agirre, X., Jimenez-Velasco, A., San Jose-Eneriz, E. et al. Methylation status of Wnt signaling pathway genes affects the clinical outcome of Philadelphia-positive acute lymphoblastic leukemia. Cancer Scie 2008; 99 (9): 1865–1868
Abstract
The clinical significance of aberrant promoter methylation of the canonical Wnt pathway antagonist genes (sFRP1, sFRP2, sFRP4, sFRP5, Wif1, Dkk3, and Hdpr1) and also putative tumor-suppressor gene Wnt5a, belonging to the non-canonical Wnt signaling pathway, was investigated in a large series of 75 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia by methylationspecific polymerase chain reaction. At least one methylated gene was observed in cells from 66% (49/75) of patients (methylated group). Disease-free survival and overall survival at 9 years were 51 and 40%, respectively, for the unmethylated group and 3 and 2%, respectively, for the methylated group (both P < 0.0001). Multivariate analysis demonstrated that the Wnt methylation profile was an independent prognostic factor predicting disease-free survival (P = 0.007) and overall survival (P = 0.039). Abnormal DNA methylation of promoter-associated CpG islands in the Wnt signaling pathway is very common in Philadelphia chromosome-positive acute lymphoblastic leukemia and potentially defines subgroups with distinct clinical characteristics.
Permanent link: http://hdl.handle.net/10171/18357
Appears in Collections:DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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