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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Terapia celular > DA - CIMA - Oncología - Terapia celular - Artículos de Revista >

Simultaneous translocations of FGFR3/MMSET and CCND1 into two different IGH alleles in multiple myeloma: lack of concurrent activation of both proto-oncogenes
Authors: Saez, B. (Borja)
Martin-Subero, J.I. (José Ignacio)
Lahortiga, I. (Idoya)
Largo, C. (Cristina)
Larrayoz, M.J. (María J.)
Odero, M.D. (María D.)
Prosper, F. (Felipe)
Cigudosa, J.C. (Juan Cruz)
Siebert, R. (Reiner)
Calasanz, M.J. (María José)
Keywords: Materias Investigacion::Ciencias de la Salud::Oncología
Issue Date: 2007
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1016/j.cancergencyto.2006.12.009
ISSN: 0165-4608
Citation: Saez, B., Martin-Subero, J. I., Lahortiga, I., Largo, C. et al . Simultaneous translocations of FGFR3/MMSET and CCND1 into two different IGH alleles in multiple myeloma: lack of concurrent activation of both proto-oncogenes. Cancer Genet. Cytogenet. 2007; 175 (1): 65-68
Abstract
The simultaneous occurrence of two different translocations affecting both alleles of the IGH gene has rarely been reported in multiple myeloma. In such a case, two different oncogenes might become transcriptionally deregulated. To investigate this hypothesis, we have characterized the plasma cell leukemia cell line SK-MM2 and a primary myeloma both carrying simultaneous IGHeFGFR3/MMSET and IGHeCCND1 fusions as shown by multicolor fluorescence in situ hybridization. Remarkably, quantitative real-time polymerase chain reaction demonstrated that only one of the oncogene loci was transcriptionally upregulated in both instances. Moreover, the upregulated oncogenes differed between both samples. Thus, biallelic IGH translocations might exert different pathogenetic effects in plasma cell disorders.
Permanent link: http://hdl.handle.net/10171/18361
Appears in Collections:DA - CIMA - Oncología - Genética - Artículos de revista
DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista
DA - Ciencias - Genética - Artículos de revista

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