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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Enfermedad vascular hipertensiva > DA - CIMA - Cardiovasculares - Enfermedad vascular - Artículos de Revista >

NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases
Authors: San-Jose, G. (Gorka)
Fortuño, A. (Ana)
Beloqui, O. (Óscar)
Diez, J. (Javier)
Zalba, G. (Guillermo)
Keywords: Cardiovascular disease
NADPH oxidase
Oxidative stress
p22phox subunit
Reactive oxygen species (ROS)
Superoxide anion
Issue Date: 2008
Publisher: Portland Press
Publisher version: http://www.clinsci.org/cs/114/cs1140173.htm
ISSN: 1470-8736
Citation: San Jose G, Fortuño A, Beloqui O, Diez J, Zalba G. NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases. Clin Sci (Lond) 2008 Feb;114(3):173-182.
Abstract
Oxidative stress plays a key role in the pathophysiology of several major cardiovascular diseases, including atherosclerosis, hypertension, heart failure, stroke and diabetes. ROS (reactive oxygen species) affect multiple tissues either directly or through NO depletion. ROS induce cardiovascular dysfunction by modulating cell contraction/dilation, migration, growth/apoptosis and extracellular matrix protein turnover, which contribute to vascular and cardiac remodelling. Of the several sources of ROS within the cardiovascular system, a family of multisubunit NADPH oxidases appears to be a predominant contributor of superoxide anion. Recent findings suggest a significant role of the genetic background in NADPH oxidase regulation. Common genetic polymorphisms within the promoter and exonic sequences of CYBA, the gene that encodes the p22(phox) subunit of NADPH oxidase, have been characterized in the context of cardiovascular diseases. This review aims to present the current state of research into these polymorphisms in their relationship to cardiovascular diseases.
Permanent link: http://hdl.handle.net/10171/18528
Appears in Collections:DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista
DA - CIMA - Cardiovasculares - Enfermedad vascular - Artículos de Revista

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