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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Terapia celular > DA - CIMA - Oncología - Terapia celular - Artículos de Revista >

A single prior course of BCNU-cisplatin chemotherapy has a significant deleterious effect on mobilization kinetics of otherwise untreated patients
Authors: Perez-Calvo, J. (Javier)
Fernandez, O. (O.)
Aristu, J. (Javier)
Aramendia, J.M. (J.M.)
Rifon, J. (José)
Prosper, F. (Felipe)
Bendandi, M. (Maurizio)
Rocha, E. (Eduardo)
Martin-Algarra, S. (Salvador)
Keywords: Mobilization
CD34
Glioma
BCNU
Transplantation
Cisplatin
Issue Date: 2004
Publisher: Nature Publishing Group
Publisher version: http://dx.doi.org/10.1038/sj.bmt.1704382
ISSN: 0268-3369
Citation: Perez-Calvo, J., Fernandez, O., Aristu, J. J., Aramendia, J. M., Rifon, J., Prosper, F. et al. A single prior course of BCNU-cisplatin chemotherapy has a significant deleterious effect on mobilization kinetics of otherwise untreated patients. Bone Marrow Transplantation 2004; 1–4
Abstract
Extensive prior treatment with cytotoxic agents is associated with impaired mobilization of hematopoietic cells. To assess the effect of a single course of standarddose chemotherapy (CT), we compared the results of filgrastim-induced mobilization among two sequential groups of grade III–IV malignant glioma patients included in a hematopoietic transplantation program. The first group (21 patients) had never been treated with CT until 2 days after surgery, when they received a course of 100 mg/m2 BCNU (IV) and 100 mg intracarotid cisplatin for cytoreduction (not for mobilization). At 1 month after this CT, they were mobilized with 12 lg/kg filgrastim. The second group (22 patients) was mobilized with the same dose of filgrastim directly after the surgery, without having ever received any prior CT. The blood level of CD34þ cells was significantly lower in the CT-treated patients, both on the fourth day of filgrastim (15 vs 36 cells 106/l; P¼0.01) and on the fifth (25 vs 58 cells 106/l; P¼0.003), as it was the number of CD34þ cells collected per apheresis (1.3 vs 3.5 106/l; Po0.0005). The toxic effect of a single course of BCNUcisplatin CT led to significant impairment of the filgrastim-induced mobilization response. Bone Marrow Transplantation advance online
Permanent link: http://hdl.handle.net/10171/18565
Appears in Collections:DA - Medicina - Oncología - Artículos de revista
DA - CIMA - Oncología - Inmunoterapia - Artículos de Revista
DA - CIMA - Oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Oncología - Terapia celular - Artículos de Revista
DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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