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Dadun > Depósito Académico > CIFA (Centro de Investigación en Farmacobiología Aplicada) > Unidad de I+D de Medicamentos > DA - CIFA - I+D de medicamentos - Artículos de revistas >

Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents
Authors: Burguete, A. (Asuncion)
Pontiki, E. (Eleni)
Hadjipavlou-Litina, D. (Dimitra)
Ancizu, S. (Saioa)
Villar, R. (Raquel)
Solano, B. (Beatriz)
Moreno-Viguri, E. (Elsa)
Torres, E. (Enrique)
Perez, S. (Silvia)
Aldana, I. (Ignacio)
Monge, A. (Antonio)
Keywords: Quinoxaline derivatives
Anti-inflammatory agents
1,4-di-N-oxide derivatives
Soybean lipoxygenase
Issue Date: 2011
Publisher: Wiley-Blackwell
Publisher version: http://dx.doi.org/10.1111/j.1747-0285.2011.01076.x
ISSN: 1747-0277
Citation: Burguete A, Pontiki E, Hadjipavlou-Litina D, Ancizu S, Villar R, Solano B, et al. Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents. Chem Biol Drug Des 2011 Apr;77(4):255-267.
Abstract
We report the synthesis, anti-inflammatory and antioxidant activities of novel quinoxaline and quinoxaline 1,4-di-N-oxide derivatives. Microwave assisted methods have been used in order to optimize reaction times and to improve the yields. The tested compounds presented important scavenging activities and promising in vitro inhibition of soybean lipoxygenase. Two of the best lipoxygenase inhibitors (compounds 7b and 8f) were evaluated as in vivo anti-inflammatory agents using the carrageenin-induced edema model. One of them (compound 7b) showed important in vivo anti-inflammatory effect (41%) similar to that of indomethacin (47%) used as the reference drug.
Permanent link: http://hdl.handle.net/10171/18591
Appears in Collections:DA - Farmacia - Orgánica - Artículos de revista
DA - CIFA - I+D de medicamentos - Artículos de revistas

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