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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Inmunoterapia > DA - CIMA - Oncología - Inmunoterapia - Artículos de Revista >

Prolonged idiotypic vaccination against follicular lymphoma
Authors: Inoges, S. (Susana)
Lopez-Diaz-de-Cerio, A. (Ascensión)
Zabalegui, N. (Natalia)
Soria, E. (Elena)
Villanueva, H. (Helena)
Panizo, C. (Carlos)
Rodriguez-Caballero, A. (Arancha)
Suarez, L. (Lilia)
Pastor, F. (Fernando)
Rodriguez-Calvillo, M. (Mercedes)
Orfao, A. (Alberto)
Bendandi, M. (Maurizio)
Keywords: Cancer Vaccines/immunology
Immunoglobulin Idiotypes/immunology
Lymphoma, Follicular/immunology
Lymphoma, Follicular/therapy
Vaccination
Issue Date: 2009
Publisher: Informa Healthcare
Publisher version: http://informahealthcare.com/doi/abs/10.1080/10428190802601122
ISSN: 1029-2403
Citation: Inoges S, Lopez-Diaz de Cerio A, Zabalegui N, Soria E, Villanueva H, Panizo C, et al. Prolonged idiotypic vaccination against follicular lymphoma. Leuk Lymphoma 2009 Jan;50(1):47-53.
Abstract
During the last 2 decades, idiotypic vaccination has provided proof of principle of biological efficacy, clinical efficacy and clinical benefit in small follicular lymphoma trials. However, with the exception of anecdotal reports, most patients have received no more than 10 doses of their customised idiotype (Id) vaccine. Therefore, it is not known whether prolonged usage of idiotypic vaccination is safe. Since 2002, 18 previously treated patients with follicular lymphoma have received extended idiotypic vaccination at our institution outside clinical trials. Vaccination was provided as a compassionate alternative to no further treatment, and was meant to be stopped only upon complete consumption of the available patient- and tumor-specific vaccine [Id-keyhole limpet hemocyanin + granulocyte-macrophage colony-stimulating factor (Id-KLH + GM-CSF)], or in case of disease relapse or any serious non-local toxicity. So far, 18 patients have received an average of 18 doses of Id vaccine (median: 17; mean: 18; range: 10-31). Eleven patients are still actively receiving idiotypic vaccination: some of them are now over more than 6 years. Toxicity has been systematically negligible and mostly local. No patient has abandoned the vaccination program because of toxicity. Prolonged idiotypic vaccination with the soluble protein Id-KLH + GM-CSF formulation is safe and well tolerated.
Permanent link: http://hdl.handle.net/10171/18680
Appears in Collections:DA - CIMA - Servicios de apoyo - Aptámeros - Artículos
DA - CIMA - Oncología - Inmunoterapia - Artículos de Revista
DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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