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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Inmunoterapia > DA - CIMA - Oncología - Inmunoterapia - Artículos de Revista >

Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer.
Authors: Arina, A. (Ainhoa)
Murillo, O. (Oihana)
Dubrot, J. (Juan)
Azpilicueta, A. (Arantza)
Alfaro, C. (Carlos)
Perez-Gracia, J.L. (José Luis)
Bendandi, M. (Maurizio)
Palencia, B. (Belén)
Hervas-Stubbs, S. (Sandra)
Melero, I. (Ignacio)
Keywords: Neoplasms/immunology
Neoplasms/therapy
T-Lymphocytes/immunology
Issue Date: 2007
Publisher: Informa Healthcare
Publisher version: http://informahealthcare.com/doi/abs/10.1517/14712598.7.5.599
ISSN: 1744-7682
Citation: Arina A, Murillo O, Dubrot J, Azpilikueta A, Alfaro C, Pérez-Gracia JL, et al. Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer. Expert Opin Biol Ther 2007 May;7(5):599-615.
Abstract
There is compelling evidence for the role of natural killer (NK) cells in tumor immunosurveillance and their beneficial effects on many experimentally successful immunotherapy strategies. NK cells mediate cell contact-dependent cellular cytotoxicity and produce pro-inflammatory cytokines, but do not rearrange antigen receptors. Their activation depends on various germline-encoded receptors, including CD16, which mediates recognition of antibody-coated target cells. NK cytotoxicity is checked by a repertoire of inhibitory receptors that scan adequate expression of major histocompatibility complex class I molecules on the potential target cell. Functional cross-talk of NK and dendritic cells suggests a critical role for NK cells in the initiation and regulation of cellular immunity. Considerable knowledge on the molecular basis of NK recognition/activation contrasts with a lack of successful translational research on these matters. However, there is plenty of opportunity for targeted intervention of inhibitory/activatory surface receptors and for adoptive cell therapy with autologous or allogeneic NK cells.
Permanent link: http://hdl.handle.net/10171/18715
Appears in Collections:DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología terapia génica - Artículos de revista
DA - CIMA - Oncología - Inmunoterapia - Artículos de Revista
DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista

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