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Dadun > Depósito Académico > CIFA (Centro de Investigación en Farmacobiología Aplicada) > Unidad de I+D de Medicamentos > DA - CIFA - I+D de medicamentos - Artículos de revistas >

New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents
Authors: Torres, E. (Enrique)
Moreno-Viguri, E. (Elsa)
Ancizu, S. (Saioa)
Barea, C. (Carlos)
Aldana, I. (Ignacio)
Monge, A. (Antonio)
Perez-Silanes, S. (Silvia)
Keywords: Anti-Tuberculosis agents
Quinoxaline 1,4-di-N-oxide derivatives
Isoniazid
Microwave assisted synthesis
Druglikeness
Issue Date: 2011
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1016/j.bmcl.2011.04.072
ISSN: 0960-894X
Citation: Torres E, Moreno E, Ancizu S, Barea C, Galiano S, Aldana I, et al. New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterium tuberculosis agents. Bioorg Med Chem Lett 2011 Jun 15;21(12):3699-3703.
Abstract
The increase in the prevalence of drug-resistant tuberculosis cases demonstrates the need of discovering new and promising compounds with antimycobacterial activity. As a continuation of our research and with the aim of identifying new antitubercular drugs candidates, a new series of quinoxaline 1,4-di-N-oxide derivatives containing isoniazid was synthesized and evaluated for in vitro anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv strain. Moreover, various drug-like properties of new compounds were predicted. Taking into account the biological results and the promising drug-likeness profile of these compounds, make them valid leads for further experimental research.
Permanent link: http://hdl.handle.net/10171/18732
Appears in Collections:DA - Farmacia - Orgánica - Artículos de revista
DA - CIFA - I+D de medicamentos - Artículos de revistas

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