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Early lung cancer detection using spiral computed tomography and positron emission tomography
Authors: Bastarrika, G. (Gorka)
Garcia-Velloso, M.J. (María José)
Lozano, M.D. (María Dolores)
Montes, U. (Usúa)
Torre, W. (Wenceslao)
Rodriguez-Spiteri, N. (Natalia)
Campo, A. (Arantza)
Seijo, L. (Luis)
Alcaide, A.B. (Ana Belén)
Pueyo, J. (Jesús)
Cano, D. (David)
Vivas, I. (Isabel)
Cosin, O. (Octavio)
Dominguez-Echavarri, P. (Pablo)
Serra, P. (Patricia)
Richter, J.A. (José Ángel)
Montuenga, L.M. (Luis M.)
Zulueta, J.J. (Javier J.)
Keywords: Chronic obstructive pulmonary disease
Lung neoplasm
Pulmonary nodule
Smoking
Issue Date: 2005
Publisher: American Thoracic Society
Publisher version: http://ajrccm.atsjournals.org/cgi/content/abstract/171/12/1378
ISSN: 1535-4970
Citation: Bastarrika G, Garcia-Velloso MJ, Lozano MD, Montes U, Torre W, Spiteri N, et al. Early lung cancer detection using spiral computed tomography and positron emission tomography. Am J Respir Crit Care Med 2005 Jun 15;171(12):1378-1383.
Abstract
RATIONALE: Lung cancer screening using computed tomography (CT) is effective in detecting lung cancer in early stages. Concerns regarding false-positive rates and unnecessary invasive procedures have been raised. OBJECTIVE: To study the efficiency of a lung cancer protocol using spiral CT and F-18-fluorodeoxyglucose positron emission tomography (FDG-PET). METHODS: High-risk individuals underwent screening with annual spiral CTs. Follow-up CTs were done for noncalcified nodules of 5 mm or greater, and FDG-PET was done for nodules 10 mm or larger or smaller (> 7 mm), growing nodules. RESULTS: A total of 911 individuals completed a baseline CT study and 424 had at least one annual follow-up study. Of the former, 14% had noncalcified nodules of 5 mm or larger, and 3.6% had nodules of 10 mm or larger. Eleven non-small cell lung cancers (NSCLC) and one small cell lung cancer (SCLC) were diagnosed in the baseline study (prevalence rate, 1.32%), and two NSCLCs in the annual study (incidence rate, 0.47%). All NSCLCs (92% of prevalence cancers) were diagnosed in stage I (12 stage IA, 1 stage IB). FDG-PET was helpful for the correct diagnosis in 19 of 25 indeterminate nodules. The sensitivity, specificity, positive predictive value, and negative predictive value of FDG-PET for the diagnosis of malignancy were 69, 91, 90, and 71%, respectively. However, the sensitivity and negative predictive value of the screening algorithm, which included a 3-month follow-up CT for nodules with a negative FDG-PET, was 100%. CONCLUSION: A protocol for early lung cancer detection using spiral CT and FDG-PET is useful and may minimize unnecessary invasive procedures for benign lesions.
Permanent link: http://hdl.handle.net/10171/18803
Appears in Collections:DA - Medicina - Radiología - Artículos de revista
DA - CUN - Radiología - Artículos de revista
DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Oncología - Biomarcadores - Artículos de Revista

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