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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Biomarcadores > DA - CIMA - Oncología - Biomarcadores - Artículos de Revista >

Targeting hypoxia and angiogenesis through HIF-1alpha inhibition
Authors: Diaz-Gonzalez, J.A. (Juan Antonio)
Russell, J. (James)
Rouzaut, A. (Ana)
Gil-Bazo, I. (Ignacio)
Montuenga, L.M. (Luis M.)
Keywords: Hypoxia
Angiogenesis
HIF-1a
Molecular inhibitors
Targeted therapy
Molecular imaging
Molecular therapy
Issue Date: 2005
Publisher: Landes Bioscience
Publisher version: http://www.landesbioscience.com/journals/cbt/article/2195/
ISSN: 1538-4047
Citation: Diaz-Gonzalez JA, Russell J, Rouzaut A, Gil-Bazo I, Montuenga L. Targeting hypoxia and angiogenesis through HIF-1alpha inhibition. Cancer Biol Ther 2005 Oct;4(10):1055-1062.
Abstract
Hypoxia is an important phenomenon in the tumor microenvironment. Hypoxic tumors are more aggressive and resistant to anti-neoplastic treatments. HIF-1alpha plays a major role in the response of tumors to hypoxia, and it is mainly responsible for the "angiogenic switch". HIF-1alpha contributes to tumor aggressiveness, invasiveness, and resistance to radiotherapy and chemotherapy. Targeting HIF-1alpha is an attractive strategy, with the potential for disrupting multiple pathways crucial for tumor growth. We review recent findings on the potential efficacy of small molecules to downregulate HIF-1alpha. These promising drugs inhibit HIF-1alpha synthesis or transcriptional activity by blocking a variety of steps in several different signaling pathways. Blocking HIF-1alpha activity should not only downregulate tumor angiogenesis, but also interfere with glycolytic metabolism and tumor cell growth. This strategy could also improve the efficiency of established tumor therapies.
Permanent link: http://hdl.handle.net/10171/18805
Appears in Collections:DA - CIMA - Oncología - Microambiente tumoral - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Hepatología bioquímica - Artículos de revista
DA - Ciencias - Bioquímica y Biología molecular - Artículos de Revista
DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Oncología - Biomarcadores - Artículos de Revista

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