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http://hdl.handle.net/10171/19206
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| Title: | In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188 |
| Author(s) : | Espuelas, S. (S.)
Legrand, P. (P.)
Loiseau, P.M. (P.M.)
Bories, C. (C.)
Barratt, G. (G.)
Irache, J.M. (Juan Manuel) |
| Issue Date: | 2000 |
| Publisher: | American Society for Microbiology |
| Citation: | Espuelas S, Legrand P, Loiseau PM, Bories C, Barratt G, Irache JM. In vitro reversion of amphotericin B resistance in leishmania donovani by poloxamer 188. Antimicrob Agents Chemother. 2000 Aug;44(8):2190-2. |
| Keywords: | Leishmania donovani
Poloxamer 188
Amphotericin B Resistance |
| Abstract: | A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an
AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association
against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of the
new formulation was 100 times less than that of the control AmB formulation. |
| URI: | http://hdl.handle.net/10171/19206 |
| Publisher version (URL): | http://aac.asm.org/cgi/content/full/44/8/2190 |
| Appears in Collections: | DA - Farmacia - Tecnología Farmacéutica - Artículos de revista
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