Dadun/></a>
				</td>
				<td class= Dadun
   (New user)
Help  | Contact  |  Castellano English  
 

Dadun > Depósito Académico > Facultad de Farmacia > Departamento de Ciencias de la Alimentación, Fisiología y Toxicología > DA - Farmacia - CAFT - Artículos de revista >

Il6 gene promoter polymorphism (-174G/C) influences the association between fat mass and cardiovascular risk factors
Authors: Moleres, A. (Adriana)
Rendo-Urteaga, T. (Tara)
Azcona, C. (C.)
Martinez, J.A. (José Alfredo)
Gomez-Martinez, S. (Sonia)
Ruiz, J.R. (J.R.)
Moreno, L.A. (Luis A.)
Marcos, A. (Ascensión)
Marti, A. (Amelia)
Keywords: Obesity
Adolescents
Polymorphism
IL6
Issue Date: 2009
Publisher: Springer Verlag
Publisher version: http://dx.doi.org/10.1007/BF03185936
ISSN: 1138-7548
Citation: Moleres A, Rendo-Urteaga T, Azcona C, Martinez JA, Gomez-Martinez S, Ruiz JR, et al. Il6 gene promoter polymorphism (-174G/C) influences the association between fat mass and cardiovascular risk factors. J Physiol Biochem. 2009 Dec;65(4):405-13.
Abstract
During the last decades, the prevalence of obesity has increased rapidly among young people. A polymorphism in the promoter region of the IL6 gene (-174G/C), has been previously reported to be involved in obesity and metabolic syndrome development. Therefore, the aim of the study was to examine whether the IL6 -174G/C polymorphism influence the association of body fat with low-grade inflammatory markers and blood lipids and lipoproteins in Spanish adolescents. 504 Spanish adolescents participating in the AVENA study were genotyped for the -174G/C polymorphism of the IL6 gene. Anthropometric and body composition measurements were taken and blood samples were collected for plasma molecules determinations. No differences between genotypes were observed in anthropometric values, body composition measurements and plasma markers concentration. Physical activity level differ between genotypes with subjects carrying the C allele of the polymorphism being significantly (p<0.05) more active than GG subjects. The association between body fat mass and plasma glucose was influenced by the -174G/C polymorphism of the IL6 gene. Subjects carrying the C allele of the mutation seem to have higher values of lipoprotein (a) and C-reactive protein as their percentage of body fat mass increase. Our results suggest that this promoter polymorphism influences the association between adiposity and some plasma markers.
Permanent link: http://hdl.handle.net/10171/19252
Appears in Collections:DA - Farmacia - CAFT - Línea Especial de Nutrición
DA - Farmacia - CAFT - Artículos de revista

Files in This Item:
File:  ArtículoAMoleres.pdf
Description: 
Size:  107,19 kB
Format:  Adobe PDF
 View / Open 

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.