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Dadun > Depósito Académico > Facultad de Farmacia > Departamento de Ciencias de la Alimentación, Fisiología y Toxicología > DA - Farmacia - CAFT - Artículos de revista >

Dietary fatty acid distribution modifies obesity risk linked to the rs9939609 polymorphism of the fat mass and obesity-associated gene in a Spanish case-control study of children
Authors: Moleres, A. (Adriana)
Ochoa, M.C. (María Carmen)
Rendo-Urteaga, T. (Tara)
Martinez-Gonzalez, M.A. (Miguel Angel)
Azcona-San-Julian, M.C. (María Cristina)
Martinez, J.A. (José Alfredo)
Marti, A. (Amelia)
Keywords: Childhood obesity
Fatty acids intake
FTO
Obesity risk
Issue Date: 2011
Publisher: Cambridge University Press
Publisher version: http://dx.doi.org/10.1017/S0007114511003424
ISSN: 0007-1145
Citation: Moleres A, Ochoa MC, Rendo-Urteaga T, Martinez-Gonzalez MA, Azcona San Julian MC, Martinez JA, et al. Dietary fatty acid distribution modifies obesity risk linked to the rs9939609 polymorphism of the fat mass and obesity-associated gene in a spanish case-control study of children. Br J Nutr. 2012 Feb;107(4):533-82.
Abstract
The rs9939609 polymorphism of the FTO gene has been widely associated with childhood obesity in several European cohorts. This association appears to be depending on dietary macronutrients. Therefore, our aim was to evaluate whether dietary fatty acid distribution intake could interact with this FTO genetic variation and obesity in a Spanish children and adolescents case-control study. 354 Spanish children and adolescents aged 6-18 (49% males) were genotyped for the rs9939609 variant of the FTO gene. Anthropometric parameters were taken and energy intake was measured. We observed an interaction between the percentage of saturated fatty acids (SFA) of diet over total energy intake as well as polyunsaturated/saturated (PUFA/SFA) fatty acid ratio and the association of the polymorphism with obesity risk. In our population the risk allele carriers consuming more than 12.6% SFA of their total energy value had an increased obesity risk compared with TT carriers. In the same way, A allele carriers that intake less than 0.43 PUFA/SFA ratio presented higher obesity risk than non A allele carriers. In summary, this study reports for the first time, the influence of dietary fatty acid distribution on the effect of the rs9939609 polymorphism of the FTO gene on obesity risk.
Permanent link: http://hdl.handle.net/10171/19253
Appears in Collections:DA - Farmacia - CAFT - Línea Especial de Nutrición
DA - Medicina - MPSP -Artículos de revista
DA - Farmacia - CAFT - Artículos de revista

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