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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Genética > DA - CIMA - Oncología - Genética - Artículos de revista >

FISH analysis of hematological neoplasias with 1p36 rearrangements allows the definition of a cluster of 2.5 Mb included in the minimal region deleted in 1p36 deletion syndrome
Authors: Lahortiga, I. (Idoya)
Vazquez, I. (Iria)
Belloni, E. (E.)
Roman, J.P. (José P.)
Gasparini, P. (P.)
Novo, F.J. (Francisco Javier)
Zudaire, I. (Isabel)
Pelicci, P.G. (Pier G.)
Hernandez, J.M. (J. M.)
Calasanz, M.J. (María José)
Odero, M.D. (María D.)
Keywords: Hematologic Neoplasms/genetics
Chromosome Aberrations
Chromosome Breakage
Chromosome Deletion
Chromosomes, Human, Pair 1
Issue Date: 2005
Publisher: Springer Verlag
Publisher version: http://www.springerlink.com/content/wxn9kvmnu7l1fju7/
ISSN: 1432-1203
Citation: Lahortiga I, Vazquez I, Belloni E, Roman JP, Gasparini P, Novo FJ, et al. FISH analysis of hematological neoplasias with 1p36 rearrangements allows the definition of a cluster of 2.5 Mb included in the minimal region deleted in 1p36 deletion syndrome. Hum Genet 2005 May;116(6):476-485
Abstract
Rearrangements in the distal region of the short arm of chromosome 1 are recurrent aberrations in a broad spectrum of human neoplasias. However, neither the location of the breakpoints (BP) on 1p36 nor the candidate genes have been fully determined. We have characterized, by fluorescence in situ hybridization (FISH), the BP in 26 patients with hematological neoplasias and 1p36 rearrangements in the G-banding karyotype. FISH allowed a better characterization of all samples analyzed. Nine cases (35%) showed reciprocal translocations, 15 (58%) unbalanced rearrangements, and two (7%) deletions. We describe two new recurrent aberrations. In 18 of the 26 cases analyzed the BP were located in band 1p36, which is 25.5 Mb long. In 14 of these 18 cases (78%) and without distinction between myeloid and lymphoid neoplasias, the BP clustered in a 2.5 Mb region located between 1p36.32 and the telomere. Interestingly, this region is contained in the 10.5 Mb cluster on 1p36.22-1pter defined in cases with 1p36 deletion syndrome. The 2.5 Mb region, located on 1p36.32-1pter, has a higher frequency of occurrence of tandem repeats and segmental duplications larger than 1 kb, when compared with the 25.5 Mb of the complete 1p36 band. This could explain its proneness for involvement in chromosomal rearrangements in hematological neoplasias.
Permanent link: http://hdl.handle.net/10171/19455
Appears in Collections:DA - CIMA - Oncología - Genética - Artículos de revista
DA - Ciencias - Genética - Artículos de revista

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