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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neurofarmacología y conducta > DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista >

Activation of human T helper 1 and DNAase expression in CD4+ T cells induced by short immunomodulating peptides.
Authors: Lopez-Moratalla, N. (Natalia)
Migliacio, M. (Marco)
Lopez-Zabalza, M. (María J.)
Perez-Mediavilla, L.A. (Luis Alberto)
Santiago, E. (Esteban)
Keywords: CD4-Positive T-Lymphocytes/drug effects
Deoxyribonucleases/biosynthesis
Peptides/pharmacology
Th1 Cells/drug effects
Adjuvants, Immunologic
Issue Date: 1994
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1006/bbrc.1994.2906
ISSN: 0006-291X
Citation: Lopez-Moratalla N, Migliacio M, Lopez-Zabalza MJ, Perez-Mediavilla A, Santiago E. Activation of human T helper 1 and DNAase expression in CD4+ T cells induced by short immunomodulating peptides. Biochem Biophys Res Commun,1994 Dec 30;205(3):2008-2012.
Abstract
Activation of human T helper 1 cells took place when lymphomononuclear cells from healthy donors were incubated in the presence of short synthetic peptides encompassing sequences present in extracellular matrix proteins. Active peptides conformed to a common structural pattern ("2-6-11 motif") [N.López-Moratalla et al., Biochem. Biophys. Acta (1994) 1221, 153-158] conferring immunomodulating properties. The release of IL-2 and IFN gamma, as well as LAK and NK-dependent cytotoxicity induced by these peptides, could be blocked by anti-HLA-DR antibody. Activated CD4+ cells isolated from the mixed incubated population contained secretion granules with DNAase activity. These results suggest that these immunomodulating peptides presented by HLA-II play a key role in the differentiation of CD4+ T cells towards a Th1 functional phenotype.
Permanent link: http://hdl.handle.net/10171/19499
Appears in Collections:DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista
DA - Ciencias - Bioquímica y Biología molecular - Artículos de Revista

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