Dadun Dadun cabecera universidad cabecera biblioteca
   (New user)
Help  | Contact  |  Castellano English  
 

Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Genética > DA - CIMA - Oncología - Genética - Artículos de revista >

NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2
Authors: Lahortiga, I. (Idoya)
Belloni, E. (E.)
Vazquez, I. (Iria)
Aguirre, X. (Xavier)
Larrayoz, M.J. (María J.)
Vizmanos, J.L. (José Luis)
Valgañon, M. (Mikel)
Zudaire, I. (Isabel)
Saez, B. (Borja)
Mateos, M.C. (María C.)
Di-Fiore, P.P. (Pier Paolo)
Calasanz, M.J. (María José)
Odero, M.D. (María D.)
Keywords: Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 7
Translocation, Genetic
Issue Date: 2005
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/S016546080400305X
ISBN: 1873-4456
Citation: Lahortiga I, Belloni E, Vazquez I, Agirre X, Larrayoz MJ, Vizmanos JL, et al. NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2. Cancer Genet Cytogenet 2005 Mar;157(2):151-156.
Abstract
The t(7;11)(p15;p15.4) has been reported to fuse the NUP98 gene (11p15), a component of the nuclear pore complex, with the class-1 homeobox gene HOXA9 at 7p15. This translocation has been associated with myeloid leukemias, predominantly acute myeloid leukemia (AML) M2 subtype with trilineage myelodysplastic features, and with a poor prognosis. The derived fusion protein retains the FG repeat motif of NUP98 N-terminus and the homeodomain shared by the HOX genes, acting as an oncogenic transcription factor critical for leukemogenesis. We report here a new complex t(7;11)-variant, i.e., t(7;11;13;17)(p15;p15;p?;p1?2) in a patient with AML-M2 and poor prognosis. The NUP98-HOXA9 fusion transcript was detected by RT-PCR, suggesting its role in the malignant transformation as it has been postulated for other t(7;11)-associated leukemias. No other fusion transcripts involving the NUP98 or HOXA9 genes were present, although other mechanisms involving several genes on chromosomes 13 and 17 may also be involved. To our knowledge, this is the first t(7;11) variant involving NUP98 described in hematological malignancies.
Permanent link: http://hdl.handle.net/10171/19526
Appears in Collections:DA - CIMA - Oncología - Genética - Artículos de revista
DA - Ciencias - Genética - Artículos de revista

Files in This Item:
File:  2005 CGC NUP-HOX.pdf
Description: 
Size:  220,26 kB
Format:  Adobe PDF
 View / Open 

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.