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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neurofarmacología y conducta > DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista >

Inducible nitric oxide synthase in human lymphomononuclear cells activated by synthetic peptides derived from extracellular matrix proteins.
Authors: Perez-Mediavilla, L.A. (Luis Alberto)
Lopez-Zabalza, M. (María J.)
Calonge-Domínguez, M. (María)
Montuenga, L.M. (Luis M.)
Lopez-Moratalla, N. (Natalia)
Santiago, E. (Esteban)
Keywords: Nitric oxide synthase (inducible)
NO release
Human lymphomononuclear cell
Immunocytochemistry
Extracellular matrix protein
Issue Date: 1995
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1016/0014-5793(94)01322-R
ISSN: 0014-5793
Citation: Perez-Mediavilla A, Lopez-Zabalza MJ, Calonge M, Montuenga L, Lopez-Moratalla N, Santiago E. Inducible nitric oxide synthase in human lymphomononuclear cells activated by synthetic peptides derived from extracellular matrix proteins. FEBS Lett 1995 Jan 3;357(2):121-124.
Abstract
Synthetic peptides with sequences present in extracellular matrix proteins are capable of causing the expression of the inducible form of nitric oxide synthase (iNOS), detected by immunocytochemistry, and the release of NO by human lymphomononuclear cells incubated in their presence. Active peptides are 15-mers containing a characteristic 2-6-11 motif in which the amino acid residue at position 2 is Leu, Ile, Val, Gly, Ala or Lys; the residue at position 6 is always Pro; and residue 11 is Glu or Asp. The induction of iNOS in human monocytes and macrophages could be involved in the cytotoxicity against tumor cell lines also elicited by these peptides.
Permanent link: http://hdl.handle.net/10171/19570
Appears in Collections:DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista
DA - Ciencias - Bioquímica y Biología molecular - Artículos de Revista
DA - CIMA - Oncología - Biomarcadores - Artículos de Revista

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