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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Genética > DA - CIMA - Oncología - Genética - Artículos de revista >

NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder
Authors: Vizmanos, J.L. (José Luis)
Novo, F.J. (Francisco Javier)
Roman, J.P. (José P.)
Baxter, E.J. (E.J.)
Lahortiga, I. (Idoya)
Larrayoz, M.J. (María J.)
Odero, M.D. (María D.)
Giraldo, P. (P.)
Calasanz, M.J. (María José)
Cross, N.C.P. (Nicholas C.P.)
Keywords: Antineoplastic Agents/therapeutic use
Myeloproliferative Disorders/drug therapy/genetics
Oncogene Proteins, Fusion/genetics
Piperazines/therapeutic use
Pyrimidines/therapeutic use
Receptor Protein-Tyrosine Kinases/genetics
Receptor, Platelet-Derived Growth Factor beta/genetics
Issue Date: 2004
Publisher: American Association for Cancer Research
Publisher version: http://cancerres.aacrjournals.org/content/64/8/2673
ISSN: 1538-7445
Citation: Vizmanos JL, Novo FJ, Roman JP, Baxter EJ, Lahortiga I, Larrayoz MJ, et al. NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder. Cancer Res 2004 Apr 15;64(8):2673-2676.
Abstract
We describe a new PDGFRB fusion associated with a t(5;14)(q33;q24) in a patient with a longstanding chronic myeloproliferative disorder with eosinophilia. After confirmation of PDGFRB involvement and definition of the chromosome 14 breakpoint by fluorescence in situ hybridization, candidate partner genes were selected on the basis of the presence of predicted oligomerization domains believed to be an essential feature of tyrosine kinase fusion proteins. We demonstrate that the t(5;14) fuses PDGFRB to NIN, a gene encoding a centrosomal protein with CEP110-like function. After treatment with imatinib, the patient achieved hematological and cytogenetical remission, but NIN-PDGFRB mRNA remained detectable by reverse transcription-PCR.
Permanent link: http://hdl.handle.net/10171/19576
Appears in Collections:DA - CIMA - Oncología - Genética - Artículos de revista
DA - Ciencias - Genética - Artículos de revista

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