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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Genética > DA - CIMA - Oncología - Genética - Artículos de revista >

Secondary myelodysplastic syndrome after treatment for promyelocytic leukemia: clinical and genetic features of two cases
Authors: Panizo, C. (Carlos)
Patiño, A. (Ana)
Lecumberri, R. (Ramón)
Calasanz, M.J. (María José)
Odero, M.D. (María D.)
Bendandi, M. (Maurizio)
Rocha, E. (Eduardo)
Keywords: Leukemia, Promyelocytic, Acute/complications/drug therapy/genetics
Myelodysplastic Syndromes/complications/genetics/pathology
Issue Date: 2003
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/S0165460802008592
ISSN: 1873-4456
Citation: Panizo C, Patiño A, Lecumberri R, Calasanz MJ, Odero MD, Bendandi M, et al. Secondary myelodysplastic syndrome after treatment for promyelocytic leukemia: clinical and genetic features of two cases. Cancer Genet Cytogenet 2003 Jun;143(2):178-181.
Abstract
Acute promyelocytic leukemia (APL) represents a biologic and clinically well-defined subtype of acute nonlymphocytic leukemia with specific morphologic and karyotypic characteristics. Although secondary leukemia and myelodysplastic syndromes (MDS) are the most frequent secondary neoplasms following chemotherapy for acute leukemia, their development after complete remission in patients with APL is uncommon. We describe the clinical and genetic features of two APL patients who achieved CR after chemotherapy and all-trans retinoid acid treatment and subsequently developed a MDS. Therapy-related MDS karyotype changes such as abnormalities of chromosomes 5 and 7 were found in the cytogenetic analysis. Since TP53 alteration was detected in one case, possible implications of these findings in the onset of MDS are discussed.
Permanent link: http://hdl.handle.net/10171/19584
Appears in Collections:DA - CIMA - Oncología - Inmunoterapia - Artículos de Revista
DA - CIMA - Oncología - Genética - Artículos de revista
DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CUN - Área de Terapia Celular - Artículos de revista
DA - Medicina - Hematología - Artículos de revista
DA - Ciencias - Genética - Artículos de revista

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