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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neurofarmacología y conducta > DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista >

HPA axis dysregulation associated to apolipoprotein E4 genotype in Alzheimer's disease
Authors: Gil-Bea, F.J. (Francisco J.)
Aisa, B. (Bárbara)
Solomon, A. (Alina)
Solas, M. (Maite)
Mugueta, C. (Carmen)
Winblad, B. (Bengt)
Kivipelto, M. (Miia)
Cedazo-Minguez, A. (Ángel)
Ramirez, M.J. (María Javier)
Keywords: 
Cerebrospinal fluid
Cortisol
Frontal cortex
Glucocorticoid receptor
Mild cognitive impairment
mineralocorticoid receptor
Mini-Mental Status Examination
Issue Date: 2010
Publisher: IOS Press
Publisher version: http://dx.doi.org/10.3233/JAD-2010-100663
ISSN: 1387-2877
Citation: Gil-Bea FJ, Aisa B, Solomon A, Solas M, del Carmen Mugueta M, Winblad B, et al. HPA axis dysregulation associated to apolipoprotein E4 genotype in Alzheimer's disease. J Alzheimers Dis 2010;22(3):829-838.
Abstract
The present work investigated the involvement of cortisol and its receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), in Alzheimer's disease (AD). Cortisol was measured in cerebrospinal fluid (CSF) samples from controls, mild cognitive impairment (MCI), progressive MCI evolving to AD, and AD. CSF cortisol levels do not seem to have a prognostic value, as increases in cortisol levels were found only in AD patients. GR expression was decreased while MR expression was increased in the frontal cortex of AD. When considering degeneration (ratio to synaptophysin and the post-synaptic marker PSD95), GR expression was similar between controls and AD, suggesting that GR loss was due to synaptic degeneration in AD. Increases in cortisol levels and MR expression were associated to an apolipoprotein E4 genotype. Cognitive status was negatively associated to CSF cortisol. In apolipoprotein E4 carriers, MR but not GR expression, negatively correlated to Mini-Mental Status Examination score and positively correlated to frontal cortex amyloid-β levels. It is concluded that there is a dysregulation of the hypothalamus-pituitary-adrenal axis in AD that seems to be consequence rather than cause of AD.
Permanent link: http://hdl.handle.net/10171/19586
Appears in Collections:DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista
DA - Farmacia - Farmacología - Artículos de revista

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