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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Cardiopatía hipertensiva > DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista >

Cardiomyocyte apoptosis in hypertensive cardiomyopathy
Authors: Gonzalez, A. (Arantxa)
Fortuño, M.A. (María Antonia)
Querejeta, R. (Ramón)
Ravassa, S. (Susana)
Lopez, B. (Begoña)
Lopez, N. (Natalia)
Diez, J. (Javier)
Keywords: Apoptosis
Arterial hypertension
Cardiomyocytes
Heart failure
Issue Date: 2003
Publisher: Oxford University Press (OUP)
Publisher version: http://dx.doi.org/10.1016/S0008-6363(03)00498-X
ISSN: 0008-6363
Citation: Gonzalez A, Fortuño MA, Querejeta R, Ravassa S, Lopez B, Lopez N, et al. Cardiomyocyte apoptosis in hypertensive cardiomyopathy. Cardiovasc Res 2003 Sep 1;59(3):549-562.
Abstract
It is widely accepted that there are two principal forms of cell death; namely, necrosis and apoptosis. According to the classical view, necrosis is the major mechanism of cardiomyocyte death in cardiac diseases. However, in the past few years observations have been made showing that cardiomyocyte apoptosis occurs in diverse conditions and that apoptosis may be a contributing cause of the loss and functional abnormalities of cardiomyocytes with important pathophysiological consequences. In this regard, although a number of formal proofs are pending, it is conceivable that cardiomyocyte apoptosis may be an important variable in the clinical evolution of hypertensive cardiomyopathy. This review summarizes recent evidence demonstrating that cardiomyocyte apoptosis is abnormally stimulated in the heart of animals and humans with arterial hypertension. In addition, the potential mechanisms of cardiomyocyte apoptosis in hypertension and its detrimental impact on cardiac function will be addressed. Finally, the perspectives of strategies aimed to detect and modulate apoptosis of cardiomyocytes in hypertensive cardiomyopathy will be considered.
Permanent link: http://hdl.handle.net/10171/19657
Appears in Collections:DA - CIMA - Servicios de apoyo - Biobanco - Artículos de revista
DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista

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