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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neurofarmacología y conducta > DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista >

Cardiotrophin-1 is a key regulator of glucose and lipid metabolism
Authors: Moreno-Aliaga, M.J. (María Jesús)
Perez-Echarri, N. (Nerea)
Marcos-Gomez, B. (Beatriz)
Larequi, E. (Eduardo)
Gil-Bea, F.J. (Francisco J.)
Viollet, B. (Benoit)
Gimenez, I. (I.)
Martinez, J.A. (José Alfredo)
Prieto, J. (Jesús)
Bustos, M. (Matilde)
Keywords: Cardiotrophin-1
rCT-1
Insulin resistance
Obesity
Issue Date: 2011
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1016/j.cmet.2011.05.013
ISSN: 1550-4131
Citation: Moreno-Aliaga MJ, Perez-Echarri N, Marcos-Gomez B, Larequi E, Gil-Bea FJ, Viollet B, et al. Cardiotrophin-1 is a key regulator of glucose and lipid metabolism. Cell Metab 2011 Aug 3;14(2):242-253.
Abstract
Cardiotrophin-1 (CT-1) is a member of the gp130 family of cytokines. We observed that ct-1(-/-) mice develop mature-onset obesity, insulin resistance, and hypercholesterolemia despite reduced calorie intake. Decreased energy expenditure preceded and accompanied the development of obesity. Acute treatment with rCT-1 decreased blood glucose in an insulin-independent manner and increased insulin-stimulated AKT phosphorylation in muscle. These changes were associated with stimulation of fatty acid oxidation, an effect that was absent in AMPKα2(-/-) mice. Chronic rCT-1 treatment reduced food intake, enhanced energy expenditure, and induced white adipose tissue remodeling characterized by upregulation of genes implicated in the control of lipolysis, fatty acid oxidation, and mitochondrial biogenesis and genes typifying brown fat phenotype. Moreover, rCT-1 reduced body weight and corrected insulin resistance in ob/ob and in high-fat-fed obese mice. We conclude that CT-1 is a master regulator of fat and glucose metabolism with potential applications for treatment of obesity and insulin resistance.
Permanent link: http://hdl.handle.net/10171/19668
Appears in Collections:DA - Farmacia - CAFT - Línea Especial de Nutrición
DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista
DA - Farmacia - CAFT - Artículos de revista

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