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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neuroanatomía ganglios basales > DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista >

Distribution of relaxin-3 mRNA and immunoreactivity and RXFP3-binding sites in the brain of the macaque, Macaca fascicularis
Authors: Ma, S. (Sherie)
Shen, P.J. (Pei-Juan)
Sang, Q. (Qian)
Lanciego, J.L. (José Luis)
Gundlach, A.L. (A. L.)
Keywords: Relaxin-3
RXFP3 (GPCR135)
Primate brain
Septum, hippocampus
Interpeduncular nucleus
Immunohistochemistry
Radioligand-binding autoradiography
Issue Date: 2009
Publisher: New York Academy of Sciences
Publisher version: http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.03954.x/abstract
ISSN: 1749-6632
Citation: Ma S, Shen PJ, Sang Q, Lanciego JL, Gundlach AL. Distribution of relaxin-3 mRNA and immunoreactivity and RXFP3-binding sites in the brain of the macaque, Macaca fascicularis. Ann N Y Acad Sci 2009 Apr;1160:256-258.
Abstract
This study examined the presence and distribution of relaxin-3 (RLN3) and its receptor, RXFP3, throughout the brain of Macaca fascicularis. In perfusion-fixed sections, RLN3 immunoreactivity (IR) was observed throughout the fore-, mid-, and hindbrain and was enriched in the septum, hippocampus, and interpeduncular and supramammillary nuclei. Neurons in the pontine central gray area contained RLN3-IR and RLN3 mRNA. The distribution of RXFP3 protein, mapped by autoradiography of [(125)I]R3/I5-binding sites, correlated with the distribution of RLN3-IR. The broad distributions of RLN3-positive neuronal axons and terminals and of RXFP3 in the brain of Macaca fascicularis are consistent with findings in the rat and with an important role for RLN3 signaling in nonhuman primate and human brain.
Permanent link: http://hdl.handle.net/10171/19833
Appears in Collections:DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista

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