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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neuroanatomía ganglios basales > DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista >

The search for a role of the caudal intralaminar nuclei in the pathophysiology of Parkinson's disease
Authors: Lanciego, J. (J.L.)
Lopez, I.P. (Iciar P.)
Rico, A.J. (Alberto J.)
Aymerich, M.S. (María S.)
Perez-Manso, M. (Mónica)
Conte, L. (L.)
Combarro, C. (C.)
Roda, E. (Elvira)
Molina, C. (Carmen)
Gonzalo, N. (Nancy)
Castle, M. (M.)
Tuñon, T. (Teresa)
Erro, E. (E.)
Barroso-Chinea, P. (P.)
Keywords: Basal ganglia
Thalamus
Deep brain stimulation
Neurodegeneration
Issue Date: 2009
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/S036192300800292X
ISSN: 1873-2747
Citation: Lanciego JL, Lopez IP, Rico AJ, Aymerich MS, Perez-Manso M, Conte L, et al. The search for a role of the caudal intralaminar nuclei in the pathophysiology of Parkinson's disease. Brain Res Bull 2009 Feb 16;78(2-3):55-59.
Abstract
The situation of the caudal intralaminar thalamic nuclei within basal ganglia circuits has gained increased attention over the past few years. Although initially considered as a "non-specific" thalamic nuclei, tract-tracing studies carried out over the past two decades have demonstrated that the centromedian-parafascicular thalamic complex (CM-Pf) is connected to virtually all basal ganglia components and related nuclei. Although the anatomical basis sustaining the thalamic modulation of basal ganglia circuits has long been characterized, the functional significance of these transverse circuits still remain to be properly accommodated within the basal ganglia model, both under normal conditions as well as in situations of dopaminergic depletion. However, the recent demonstration of primary (e.g., non-dopamine related) neurodegenerative phenomena restricted to the CM-Pf in Parkinson's disease (PD) has renewed interest in the role played by the caudal intralaminar nuclei in the pathophysiology of PD. Concomitantly, evidence has become available of increased metabolic activity in the caudal intralaminar nuclei in rodent models of PD. Finally, CM-Pf neurosurgery in patients suffering from PD has produced contrasting outcomes, indicating that a consensus is still to be reached regarding the potential usefulness of targeting the caudal intralaminar nuclei to treat movement disorders of basal ganglia origin.
Permanent link: http://hdl.handle.net/10171/19834
Appears in Collections:DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista

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