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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Cardiopatía hipertensiva > DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista >

The use of collagen-derived serum peptides for the clinical assessment of hypertensive heart disease
Authors: Lopez, B. (Begoña)
Gonzalez, A. (Arantxa)
Querejeta, R. (Ramón)
Diez, J. (Javier)
Keywords: Collagen
Fibrosis
Myocardium
Peptides
Remodeling
Issue Date: 2005
Publisher: Lippincott, Williams & Wilkins
Publisher version: http://journals.lww.com/jhypertension/Abstract/2005/08000/The_use_of_collagen_derived_serum_peptides_for_the.2.aspx
ISSN: 0263-6352
Citation: Lopez B, Gonzalez A, Querejeta R, Diez J. The use of collagen-derived serum peptides for the clinical assessment of hypertensive heart disease. J Hypertens 2005 Aug;23(8):1445-1451.
Abstract
Given the importance of fibrous tissue in leading to myocardial dysfunction and failure in hypertensive heart disease, non-invasive assessment of fibrosis could prove a clinically useful tool in hypertensive patients, particularly given the potential for cardioprotective and cardioreparative pharmacological strategies. In this regard, an emerging experimental and clinical experience holds promise for the assessment of various serum peptides arising from the metabolism of collagen types I and III in arterial hypertension. More specifically, the measurement of serum concentrations of procollagen type I carboxy-terminal propeptide (a peptide that is cleaved from procollagen type I during the synthesis of fibril-forming collagen type I) may provide indirect diagnostic information on both the extent of myocardial fibrosis and the ability of antihypertensive treatment to diminish collagen type I synthesis and reduce myocardial fibrosis in hypertensive patients. The available data set the stage for large and long-term trials to definitively validate this approach.
Permanent link: http://hdl.handle.net/10171/19916
Appears in Collections:DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista

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