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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Cardiopatía hipertensiva > DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista >

Independent association of von Willebrand factor with surrogate markers of atherosclerosis in middle-aged asymptomatic subjects
Authors: Paramo, J.A. (José Antonio)
Beloqui, O. (Óscar)
Colina, I. (Inmaculada)
Diez, J. (Javier)
Orbe, J. (Josune)
Keywords: Von Willebrand factor
Atherosclerosis
Endothelial damage
Carotid intima-media thickness
Microalbuminuria
Issue Date: 2005
Publisher: Wiley-Blackwell
Publisher version: http://dx.doi.org/10.1111/j.1538-7836.2005.01305.x
ISSN: 1538-7933
Citation: Paramo JA, Beloqui O, Colina I, Diez J, Orbe J. Independent association of von Willebrand factor with surrogate markers of atherosclerosis in middle-aged asymptomatic subjects. J Thromb Haemost 2005 Apr;3(4):662-664.
Abstract
Von Willebrand factor (VWF) is considered a reliable marker of endothelial damage. Plasma levels of VWF were measured in 857 middle-aged subjects (80.4% men) free of clinically overt atherosclerotic disease, in relation to cardiovascular risk factors, carotid intima-media thickness (IMT) and microalbuminuria, two established surrogate markers of atherosclerosis. There was linear trend for the increase of VWF, carotid IMT (p < 0.001) and microalbuminuria (p = 0.018). The association between VEF and both markers remained statistically significant after adjusting for cardiovascular risk factors and inflammatory markers (p < 0.01). In conclusion, VWF was independently associated with both structural and functional surrogates of atherosclerosis in asymptomatic subjects, thus representing a systemic biomarker of subclinical atherosclerosis.
Permanent link: http://hdl.handle.net/10171/19967
Appears in Collections:DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista
DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista

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