Dadun/></a>
				</td>
				<td class= Dadun
   (New user)
Help  | Contact  |  Castellano English  
 

Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neuroanatomía ganglios basales > DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista >

Thalamic innervation of the direct and indirect basal ganglia pathways in the rat: Ipsi- and contralateral projections
Authors: Castle, M. (M.)
Aymerich, M.S. (María S.)
Sanchez-Escobar, C. (Carlos)
Gonzalo, N. (Nancy)
Obeso, J.A. (José A.)
Lanciego, J.L. (José Luis)
Keywords: Striatum
Globus pallidus
Substantia nigra
Parafascicular nucleus
Neuroanatomy
Parkinson’s disease
Issue Date: 2005
Publisher: Wiley Blackwell
Publisher version: http://bit.ly/tRmnVI
ISSN: 1096-9861
Citation: Castle M, Aymerich MS, Sanchez-Escobar C, Gonzalo N, Obeso JA, Lanciego JL. Thalamic innervation of the direct and indirect basal ganglia pathways in the rat: Ipsi- and contralateral projections. J Comp Neurol 2005 Mar 7;483(2):143-153.
Abstract
The present study describes the thalamic innervation coming from the rat parafascicular nucleus (PF) onto striatal and subthalamic efferent neurons projecting either to the globus pallidus (GP) or to the substantia nigra pars reticulata (SNr) by using a protocol for multiple neuroanatomical tracing. Both striatofugal neurons targeting the ipsilateral SNr (direct pathway) as well as striatal efferent neurons projecting to the ipsilateral GP (indirect pathway) were located within the terminal fields of the thalamostriatal afferents. In the subthalamic nucleus (STN), both neurons projecting to ipsilateral GP as well as neurons projecting to ipsilateral SNr also appear to receive thalamic afferents. Although the projections linking the caudal intralaminar nuclei with the ipsilateral striatum and STN are far more prominent, we also noticed that thalamic axons could gain access to the contralateral STN. Furthermore, a small number of STN neurons were seen to project to both the contralateral GP and PF nuclei. These ipsi- and contralateral projections enable the caudal intralaminar nuclei to modulate the activity of both the direct and the indirect pathway.
Permanent link: http://hdl.handle.net/10171/20049
Appears in Collections:DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista

Files in This Item:
File:  JCN2005.pdf
Description: 
Size:  582,54 kB
Format:  Adobe PDF
 View / Open 

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.