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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Cardiopatía hipertensiva > DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista >

Association of increased erythrocyte Na+/H+ exchanger with renal Na+ retention in patients with essential hypertension
Authors: Diez, J. (Javier)
Alonso, A. (Amalia)
Garciandia, A. (Ana)
Lopez, R. (Rafael)
Gomez-Alamillo, C. (Carlos)
Arrazola, A. (Arantxa)
Fortuño, A. (A.)
Keywords: Erythrocytes/metabolism
Hypertension/blood
Sodium/urine
Sodium-Hydrogen Antiporter/blood
Issue Date: 1995
Publisher: Nature publishing group
Publisher version: http://dx.doi.org/10.1016/0895-7061(94)00172-8
ISSN: 0895-7061
Citation: Diez J, Alonso A, Garciandia A, Lopez R, Gomez-Alamillo C, Arrazola A, et al. Association of increased erythrocyte Na+/H+ exchanger with renal Na+ retention in patients with essential hypertension. Am J Hypertens 1995 Feb;8(2):124-132.
Abstract
The goal of this study was to investigate the activity of the Na+/H+ exchanger in erythrocytes of patients with essential hypertension and its relation with urinary Na+ excretion. The study was performed in cells from 27 untreated hypertensive patients and 30 normotensive controls with similar age and sex distribution. All subjects were studied after 4 days on a controlled Na+ diet (145 mmol/day). The activity of the Na+/H+ exchanger was determined by acidifying cell pH and measuring the initial rate of the net Na(+)-dependent H+ efflux. The activity of the Na+/H+ exchanger was higher in hypertensive patients than in controls (301 +/- 45 v 162 +/- 23 mmol/L cells/h, mean +/- SEM; P < .01). With the upper limit of the normotensive population as a cut-off point (385 mmol/L cells/h), a subgroup of 12 hypertensive patients had an abnormally high activity of Na+/H+ exchanger. Compared with controls and with patients with normal exchanger activity, patients with increased exchanger activity were characterized by lower net (P < .01) and fractional (P < .05) Na+ excretion. The accumulative Na+ balance was higher (P < .01) in hypertensive patients with increased activity of the exchanger (39.90 +/- 3.47 mmol) than in the remaining hypertensive patients (0.59 +/- 6.96 mmol) or in the normotensive population (-5.71 +/- 6.12 mmol). After analyzing the relationship of renin activity with Na+ excretion it was observed that renin activity was inappropriately low in 9 (75%) patients with increased exchanger, in 6 (40%) patients with normal exchanger, and in 6 (20%) normotensives, these differences being significant (P<.01).
Permanent link: http://hdl.handle.net/10171/20100
Appears in Collections:DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista

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