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Please use this identifier to cite or link to this item:
http://hdl.handle.net/10171/20114
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| Title: | The number of dopaminergic cells is increased in the olfactory bulb of monkeys chronically exposed to MPTP |
| Author(s) : | Belzunegui, S. (S.)
San-Sebastian, W. (Waldy)
Garrido-Gil, P. (P.)
Izal-Azcarate, A. (A.)
Vazquez-Claverie, M. (Marianne)
Lopez, B. (Berta)
Marcilla, I. (Irene)
Lanciego, J. (J.L.)
Luquin, M.R. (María Rosario) |
| Issue Date: | 2007 |
| Publisher: | Wiley Blackwell |
| Citation: | Belzunegui S, San Sebastian W, Garrido-Gil P, Izal-Azcarate A, Vazquez-Claverie M, Lopez B, et al. The number of dopaminergic cells is increased in the olfactory bulb of monkeys chronically exposed to MPTP. Synapse 2007 Dec;61(12):1006-1012. |
| Keywords: | Monkey
MPTP
Parkinson’s disease
Dopaminergic cells
Olfactory bulb |
| Abstract: | We investigated the impact of the nigrostriatal lesion on the olfactory tyrosine hydroxylase-immunoreactive (TH-ir) cells in monkeys. The majority of these TH-ir cells appeared in the glomerular layer of the olfactory bulb and many were immature but functional dopaminergic neurons. In parkinsonian monkeys the number of olfactory dopaminergic neurons increased up to 100% as compared to controls, but their phenotype did not change. This increased TH-ir cell population might be a direct consequence of the nigral cell loss and contribute to the hyposmia reported by Parkinson's disease patients. |
| URI: | http://hdl.handle.net/10171/20114 |
| Publisher version (URL): | http://bit.ly/tP1VTM |
| Appears in Collections: | DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista
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