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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neuroanatomía ganglios basales > DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista >

The number of dopaminergic cells is increased in the olfactory bulb of monkeys chronically exposed to MPTP
Authors: Belzunegui, S. (S.)
San-Sebastian, W. (Waldy)
Garrido-Gil, P. (P.)
Izal-Azcarate, A. (A.)
Vazquez-Claverie, M. (Marianne)
Lopez, B. (Berta)
Marcilla, I. (Irene)
Lanciego, J. (J.L.)
Luquin, M.R. (María Rosario)
Keywords: Monkey
MPTP
Parkinson’s disease
Dopaminergic cells
Olfactory bulb
Issue Date: 2007
Publisher: Wiley Blackwell
Publisher version: http://bit.ly/tP1VTM
ISSN: 1098-2396
Citation: Belzunegui S, San Sebastian W, Garrido-Gil P, Izal-Azcarate A, Vazquez-Claverie M, Lopez B, et al. The number of dopaminergic cells is increased in the olfactory bulb of monkeys chronically exposed to MPTP. Synapse 2007 Dec;61(12):1006-1012.
Abstract
We investigated the impact of the nigrostriatal lesion on the olfactory tyrosine hydroxylase-immunoreactive (TH-ir) cells in monkeys. The majority of these TH-ir cells appeared in the glomerular layer of the olfactory bulb and many were immature but functional dopaminergic neurons. In parkinsonian monkeys the number of olfactory dopaminergic neurons increased up to 100% as compared to controls, but their phenotype did not change. This increased TH-ir cell population might be a direct consequence of the nigral cell loss and contribute to the hyposmia reported by Parkinson's disease patients.
Permanent link: http://hdl.handle.net/10171/20114
Appears in Collections:DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista

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